Evidence map›Paper›PMID 41558796›Full record

ArticleBMJ open respiratory research2026

Parental asthma and risk of offspring asthma from childhood to adolescence: a population-based cohort study.

Marianne Rørholt Grefslie, Siri Eldevik Håberg, Maria C Magnus, Tone K Omsland, Per Magnus

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Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Marianne Rørholt GrefslieCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway mariannehopen.rorholt@fhi.no.ORCID http://orcid.org/0009-0003-9651-8743
Siri Eldevik HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Maria C MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Tone K OmslandDepartment of Community Medicine and Global Health, University of Oslo, Oslo, Norway.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal asthma has been associated with a higher risk of asthma in early childhood compared with paternal asthma, but it is unclear whether this difference persists into adolescence.

methodsWe analysed 55 643 children from the Norwegian Mother, Father and Child Cohort Study. Parental asthma was self-reported during pregnancy; offspring asthma was reported by mothers at ages 3, 7 and 14 years. Logistic regression models estimated associations between parental asthma and offspring asthma at each age, adjusting for maternal age, parental prepregnancy body mass index, parental education, parental smoking and parental atopic conditions, including atopic eczema and pollen/hay fever.

resultsAsthma prevalence among offspring was 6.5% at age 3, 5.2% at age 7 and 5.4% at age 14. Compared with children of non-asthmatic parents, adjusted ORs for asthma at age 3 were 3.11 (95% CI 2.73 to 3.54) for maternal asthma only and 2.25 (95% CI 1.97 to 2.56) for paternal asthma only. Similar patterns were observed at ages 7 (maternal OR 2.96 (95% CI 2.54 to 3.45); paternal OR 2.36 (95% CI 2.03 to 2.75)) and 14 (maternal OR 3.03 (95% CI 2.46 to 3.73); paternal OR 1.95 (95% CI 1.57 to 2.43)). At age 3, maternal asthma was associated with higher odds in boys (OR 3.30) than girls (OR 2.82), and higher absolute risk (19.2% vs 12.2%). However, interaction tests by offspring sex were not statistically significant.

conclusionsMaternal asthma conferred a consistently stronger risk of offspring asthma than paternal asthma, from early childhood into adolescence. This effect appeared slightly stronger in boys in early childhood, though sex differences were not statistically significant.

Indexed as

AsthmaParentsAdolescentChildChild, PreschoolCohort StudiesFemaleHumansLogistic ModelsMaleNorwayPregnancyPrevalenceRisk FactorsAsthmaAsthma EpidemiologyAsthma MechanismsClinical EpidemiologyPaediatric asthma

Identifiers

PMID41558796
PMCPMC12820850

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