Evidence map›Paper›PMID 41558792›Full record

SynthesisBMJ paediatrics open2026

Acute kidney injury due to diarrhoeal diseases in children: a systematic review.

Lea M Merz, Nivedita Kamath, Adewale E Adetunji, Valerie A Luyckx

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ paediatrics open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lea M MerzDepartment of Pediatric Nephrology, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0009-0005-6000-6791
Nivedita KamathDepartment of Pediatric Nephrology, St John's Medical College Hospital, Bengaluru, Karnataka, India.
Adewale E AdetunjiDepartment of Pediatrics, Irrua Specialist Teaching Hospital, Irrua, Nigeria.
Valerie A LuyckxDepartment of Nephrology, University Children's Hospital, University of Zurich, Zurich, Switzerland valerie.luyckx@uzh.ch.ORCID http://orcid.org/0000-0001-7066-8135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute kidney injury (AKI) is a major health concern, disproportionately affecting children in low- and lower-middle-income countries (LLMICs). Diarrhoeal diseases, a leading cause of paediatric morbidity and mortality, are significant contributors to AKI.

methodsThis study systematically reviewed literature published post-2000 on three groups of children: those hospitalised with diarrhoea who developed AKI (Diarrhoea/AKI), those hospitalised with AKI attributable to diarrhoea (AKI/Diarrhoea), and those with diarrhoea-associated haemolytic uraemic syndrome (D

resultsAfter screening 1895 titles and abstracts, 92 studies were included. Most focused on D

conclusionDiarrhoea is a common yet underreported associated clinical finding among children with AKI, particularly in resource-limited settings. Enhanced monitoring of kidney outcomes in children with diarrhoea is essential to address the overlapping burden of these conditions and improve outcomes globally.

Indexed as

Acute Kidney InjuryDiarrheaChildDeveloping CountriesHemolytic-Uremic SyndromeHospitalizationHumansPrevalenceChild HealthNephrology

Identifiers

PMID41558792
PMCPMC12820867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.