Trial reportJournal of clinical periodontology2026
Impact of Interdental Brushing on Pregnancy-Associated Gingivitis: A Secondary Analysis of a Randomised Controlled Trial.
Trial report in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04989075 (Effect of Oral Prophylactic Measures on the Occurrence of Pre-eclampsia), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Oral Prophylactic Measures on the Occurrence of Pre-eclampsia (OP-PE) in High-risk Pregnant Women: A Cluster-randomized Controlled Trial
Who cites it
4 citing papers in PubMed.
- The Maternal Microbiome in Pregnancy: From Physiological Changes to Dysbiosis and Obstetrical Complications-Therapeutic Perspectives.Life (Basel, Switzerland) · 2026Review
- Salivary Prevalence of Four Oral Pathogens in Postpartum Women in Northeast Romania: An Exploratory Cross-Sectional Study.Pathogens (Basel, Switzerland) · 2026Article
- The oral microbiome in relation to systemic maternal conditions and pregnancy complications: a systematic review and meta-analysis.Journal of oral microbiology · 2026Review
- Oral prophylaxis for the reduction of interdental dysbiosis-associated red complex pathogens during pregnancy: a randomized clinical trial.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
aimTo assess whether daily use of calibrated interdental brushes can reduce gingival bleeding in pregnant women at high risk of preeclampsia. MATERIALS AND
methodsIn this multi-centre randomised controlled trial, 323 nulliparous women at risk of preeclampsia and with an intact periodontium were enrolled at 12 weeks of gestation. Participants were randomly allocated (1:1) to either: (i) the intervention group receiving individualised interdental hygiene instructions and calibrated interdental brushes for daily use, or (ii) the control group: receiving routine antenatal care. All participants were recalled at 1 week after baseline, 4, 5 and 8 months of pregnancy for assessments of bleeding on probing (BOP) and other periodontal indices. Linear mixed models were used to assess changes in bleeding over time, and logistic regression was used to evaluate predictors of bleeding resolution at the final follow-up.
resultsAt 8 months of pregnancy, the intervention group showed a significant reduction in gingival bleeding, from 56% at baseline to 12% (-79.9%, p < 0.001), whereas the control group remained stable. Most of the improvement occurred during the first week (-56.8%). Among participants with severe baseline bleeding (> 81%), the reduction reached 84.3% (p < 0.05). Longitudinal analysis confirmed sustained reductions at each follow-up. Interdental brushing was the strongest independent predictor of bleeding reduction (OR = 3.14; 95% CI: 2.01-4.90).
conclusionsDaily use of calibrated interdental brushes, introduced early in pregnancy, significantly reduced gingival bleeding with rapid and sustained effects. These findings support the feasibility and clinical relevance of individualised interdental hygiene as a preventive strategy within standard antenatal oral health care.
trial registrationClinicalTrials.gov NCT04989075 (https://clinicaltrials.gov/study/NCT04989075).
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