ArticleRenal failure2025
Mortality prediction in hemodialysis patients using heart rate variability and skin sympathetic nerve activity.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Patients undergoing maintenance hemodialysis (HD) face a substantially elevated risk of all-cause mortality, yet robust tools for individualized risk stratification remain limited. This multicenter study developed a predictive model integrating dynamic autonomic nervous system (ANS) markers - heart rate variability (HRV) and skin sympathetic nerve activity (SKNA) - with clinical factors to assess mortality risk. We enrolled 198 HD patients from two Chinese centers between 2021 and 2023, recording HRV/SKNA parameters at baseline, 30 min, and 240 min into dialysis. Over a median follow-up of 34 months, the all-cause mortality rate was 17.7%. Ninety-one baseline features were included in the LASSO-regression model. The final multivariable logistic regression model incorporated six variables (diabetes mellitus, DBP
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