Evidence map›Paper›PMID 41558005›Full record

ArticleBioconjugate chemistry2026

Development and Optimization of an Aminooxy Coupling Reaction to Prepare Multivalent Bioconjugates with a Single Noncanonical Amino Acid.

Robert K Gourdie, Emily L Boyt, Brian M Flood, Alexander C Williard, William I Eisen, Tyler L Skeen, Annalee R Hassler, Aaron S Wang, Cedrick R Dimaranan, Sophia K Rothman and 3 more

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Robert K GourdieDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Emily L BoytDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Brian M FloodDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Alexander C WilliardDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
William I EisenDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.ORCID 0009-0003-4210-8271
Tyler L SkeenDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Annalee R HasslerDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Aaron S WangDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Cedrick R DimarananDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Sophia K RothmanDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.
Elizabeth A KingDepartment of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States.ORCID 0000-0002-1988-3849
Jonathan C MazaDepartment of Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.
Douglas D YoungDepartment of Chemistry, William & Mary, Williamsburg, Virginia 23185, United States.ORCID 0000-0003-4433-4101

Funding

Bioconjugations Employing Unnatural Amino AcidsR15GM113203 · NIGMS · COLLEGE OF WILLIAM AND MARY · PI YOUNG, DOUGLAS · 2016 to 2025
$1.0M
NIGMS NIH HHS R15 GM113203
6 · The paper itself

Abstract

Bioconjugates have increasing utility in numerous medical and materials applications; thus, the development of new mechanisms to increase their valency and functional potential has the ability to further their impact. Expansion of the chemical tools used to prepare bioconjugates affords greater flexibility in their preparation and can improve their potency and specificity. This research integrates genetic code expansion methodologies with bioorthogonal reaction development to prepare homogeneous multivalent bioconjugates. Specifically, a novel bioorthogonal reaction has been optimized, reacting an

Indexed as

Amino AcidsAminesErb-b2 Receptor Tyrosine KinasesFluorescent DyesHumansAminesAmino AcidsErb-b2 Receptor Tyrosine KinasesFluorescent Dyes

Identifiers

PMID41558005
PMCPMC12921668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.