Evidence map›Paper›PMID 41557763›Full record

SynthesisCancer control : journal of the Moffitt Cancer Center

Dietary and Urinary Iodine in Relation to Thyroid Cancer Risk: A Meta-Analysis.

Shitao Li, Hengxu Yu

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shitao LiFirst Clinical Medical College, Shanxi Medical University, Taiyuan, China.ORCID 0009-0002-4402-5675
Hengxu YuSchoolof Medicine, Jiaxing University, Jiaxing, China.ORCID 0009-0004-5064-6990

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionThe influence of iodine on papillary thyroid carcinoma (PTC) remains a subject of debate. This meta-analysis was conducted to evaluate the risk association between varying levels of iodine intake and the occurrence of PTC and different subtypes of thyroid carcinoma (TC), particularly papillary thyroid microcarcinoma (PTMC).MethodsFour databases-the Cochrane Library, Embase, PubMed, and Web of Science-were systematically searched for relevant studies published up until May 30, 2024. An updated search was conducted on November 20, 2025. Literature screening and information collection were performed according to predefined eligibility criteria. The Newcastle-Ottawa Scale (NOS) was used to appraise the quality of the eligible literature. Statistical analysis was performed using Stata 17.ResultsThis meta-analysis encompassed 17 studies involving 273 651 individuals. The findings revealed a correlation between high urinary iodine concentrations and an increased risk of TC (odds ratio [OR]: 6.43, 95% confidence interval [CI]: 2.72-15.22,

Indexed as

DietIodineThyroid Cancer, PapillaryThyroid NeoplasmsCarcinoma, PapillaryHumansRisk FactorsIodineiodineiodine-127papillary thyroid cancerthyroid cancerthyroid neoplasms

Identifiers

PMID41557763
PMCPMC12819980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.