ArticlePloS one2026
Potential mechanisms and effects of AFB1-induced asthma: A comprehensive analysis based on network toxicology and molecular docking.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Astragaloside IV targets TUBB4B to inhibit proliferation and promote apoptosis of pituitary tumor cells via the STMN1/ERK pathway.International journal of molecular medicine · 2026Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to systematically explore the potential molecular mechanisms by which aflatoxin B1 (AFB1) may trigger asthma using network toxicology and molecular docking. Potential targets related to asthma caused by AFB1 were obtained from databases, such as PubChem, ProTox, ADMETab, and GeneCards. The targets most significantly related to asthma were further screened using STRING and Cytoscape and analyzed using GO and KEGG enrichment. Finally, molecular docking and visualization were performed using AutodockVina 1.2.2 and PyMOL 2.5 to further determine the affinity between AFB1 and the core targets. We identified 31 potential targets associated with AFB1 exposure and asthma, including PTGS2, ADRB2, CysLTR1, PTGS1, and others. The enrichment analysis revealed that the core targets of AFB1-induced asthma were neuroactive ligand‒receptor interactions, the calcium signaling pathway, and the adipocyte catabolism-related signaling pathway. Molecular docking results revealed that AFB1 exhibited good affinity for the core targets. In the present study, the potential mechanisms involved in AFB1-induced asthma were elucidated, new insights into how environmental toxins trigger asthma were provided, and a theoretical foundation for asthma prevention and treatment was established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.