Trial reportAnesthesiology2026
High-flow Nasal Oxygenation in Infants Undergoing Tracheal Intubation: A Single-center Randomized Controlled Trial.
Trial report in Anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Preoxygenation in Infants: There's Only One Way to Do It, Right?Anesthesiology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-flow nasal oxygenation (HFNO) is increasingly used as an alternative for preoxygenation and apneic oxygenation during tracheal intubation. However, its efficacy in infants remains underexplored. This study evaluated whether HFNO improves intubation outcomes compared to those with face mask ventilation in infants.
methodsThis prospective, single-center randomized controlled trial included 132 infants undergoing elective surgery under tracheal intubation. The infants were divided into HFNO and control groups, with both groups receiving 100% oxygen. The HFNO group received HFNO for preoxygenation (0.5 l · kg -1 · min -1 for 3 min), as well as during the apneic period (2 l · kg -1 · min -1 for 1 min) and laryngoscopy (2 l · kg -1 · min -1 ). The control group received face mask preoxygenation (6 l/min for 3 min), followed by face mask ventilation during the apneic period (6 l/min for 1 min) and no oxygen delivery during laryngoscopy. The primary outcome was the desaturation incidence (peripheral oxygen saturation of less than 95% for 5 s or longer) from preoxygenation to 1 min after intubation. Various secondary outcomes were also assessed.
resultsAfter exclusions, 125 infants were analyzed (HFNO: n = 60; control: n = 65). There was no statistically significant between-group difference in the incidence of oxygen saturation less than 95% (control vs . HFNO: 9.2% vs . 13.3%; relative risk, 1.44; 95% CI, 0.53 to 3.92; P = 0.658). With regard to secondary outcomes, the incidence of oxygen saturation less than 90%, first-attempt intubation success rate, lowest oxygen saturation, postintubation end-tidal carbon dioxide and oxygen, and atelectasis scores were similar between groups. Gastric insufflation was less frequent in the HFNO group; the difference was statistically significant (36.7% vs . 70.8%; P < 0.001).
conclusionsIn the current study involving the use of HFNO for preoxygenation and apneic oxygenation during tracheal intubation in infants, there was no significant difference in the incidence of desaturation between HFNO and face mask ventilation, although the former was associated with less frequent gastric insufflation.
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