Evidence map›Paper›PMID 41557248›Full record

ArticleNeurochemical research2026

Melatonin Promotes Neurogenesis via the JAK2/STAT3 Pathway in Hypoxic-Ischemic Neonatal Rats.

Yijing Wang, Miao Yu, Chenmeng Liu, Xiaozu Zhang, Youcheng Qin, Nan Meng, Ning Xue, Yinuo Li, Dianmei Liu, Jingying Jiang and 1 more

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yijing Wang *School of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Miao Yu *School of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Chenmeng LiuSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Xiaozu ZhangSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Youcheng QinSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Nan MengSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Ning XueSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Yinuo LiSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China.
Dianmei LiuDepartment of Ultrasound, Affiliated Hospital of Shandong Second Medical University, Weifang, 261031, China. liudianmei97@163.com.
Jingying JiangSchool of Biological Science and Medical Engineering & School of Engineering Medicine, Beihang University, Beijing, 100191, China. jingyingjiang@buaa.edu.cn.
Xiaoli WangSchool of Medical Imaging, Shandong Second Medical University, No. 7166, Baotong West Street, Weifang, 261053, Shandong, China. wxlpine@163.com.

Funding

Shandong medical health science and technology project 202309041351the National Natural Science Foundation of China 82071888the Natural Science Foundation of Shandong Province ZR2024MH067
6 · The paper itself

Abstract

Neonatal hypoxic-ischemic brain damage (HIBD) is a leading cause of neurological dysfunction and long-term disability in newborns. Lactate accumulation and metabolic disturbances after brain injury inhibit neurogenesis, while the restorative capacity of endogenous neural stem cells (NSCs) is essential for neural reconstruction. Melatonin (Mel) alleviates neonatal brain injury, but its effects on NSCs proliferation and migration remain unclear, and the visualization methods for dynamic monitoring of metabolic changes are inadequate. In this study, a neonatal rat model of HIBD was established, and multimodal MRI combined with histological techniques was employed to evaluate the effects of Mel on NSCs regeneration and metabolic conditions in the hippocampal dentate gyrus. Using these techniques, the potential neuroprotective effects of Mel via the JAK2/STAT3 pathway were investigated. Multimodal MRI revealed that Mel increased cerebral blood flow and oxygen saturation, reduced lactate levels, improved brain metabolic microenvironment, and alleviated brain damage caused by HIBD. EdU/Nestin and EdU/DCX staining revealed that Mel promoted the proliferation and migration of endogenous NSCs, thereby enhancing neurogenesis. In addition, the use of a JAK2 inhibitor (WP1066) and agonist (C-A1) verified that Mel exerted its protective effects by down-regulating the JAK2/STAT3 pathway. Morris water maze further confirmed that Mel improved spatial learning and memory function in neonatal rats with HIBD. Multimodal MRI offers a visual basis for monitoring metabolic changes and therapeutic effects, while Mel enhances neurogenesis and mitigates brain injury through inhibition of the JAK2/STAT3 pathway, thus providing a theoretical basis for the clinical application of Mel in HIBD in neonates.

Indexed as

Hypoxia-Ischemia, BrainJanus Kinase 2MelatoninNeurogenesisSTAT3 Transcription FactorAnimalsAnimals, NewbornCell MovementCell ProliferationDoublecortin ProteinMaleMaze LearningNeural Stem CellsNeuroprotective AgentsRatsRats, Sprague-DawleyDcx protein, ratDoublecortin ProteinJak2 protein, ratJanus Kinase 2MelatoninNeuroprotective AgentsStat3 protein, ratSTAT3 Transcription FactorHypoxic-ischemic brain damageJAK2/STAT3 pathwayMelatoninMultiparametric MRIProliferation and migration

Identifiers

PMID41557248

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.