Evidence map›Paper›PMID 41557196›Full record

ArticleTranslational stroke research2026

Collagen Imaging in Human Intracranial Aneurysms - a Translational Proof-of-Concept Study.

Katharina A M Hackenberg, Nicola Willett, Uwe Seibold, Gereon Weingarten, Rita Dreier, Natalija Pantelic, Amr Abdulazim, Gabriel J E Rinkel, Björn Wängler, Carmen Wängler and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katharina A M HackenbergDepartment of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Germany. katharina.hackenberg@umm.de.ORCID http://orcid.org/0000-0003-4093-1507
Nicola WillettDepartment of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Germany.
Uwe SeiboldBiomedical Chemistry, Clinic for Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Gereon WeingartenInstitute for Nuclear Physics (IKP), Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.
Rita DreierInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Münster, Germany.
Natalija PantelicDepartment of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Germany.
Amr AbdulazimDepartment of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Germany.
Gabriel J E RinkelDepartment of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Germany.
Björn WänglerMolecular Imaging and Radiochemistry, Clinic for Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Carmen WänglerBiomedical Chemistry, Clinic for Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Nima EtminanDepartment of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unruptured intracranial aneurysms (IAs) are highly prevalent in the general population and there is an unmet need for radiological surrogates for the assessment of an increased risk of rupture. High turnover of type I collagen, i.e. abundant proportions of newly synthesized, immature collagen, has been linked to structural instability of the IA wall. This study aimed to test a newly synthesized positron emission tomography tracer that could selectively visualize immature type I collagen in human IAs as a marker for structural instability and thereby increased rupture risk. Following the synthesis of [

Indexed as

CollagenCollagen Type IIntracranial AneurysmPositron-Emission TomographyAdultAgedAneurysm, RupturedAnimalsCross-Sectional StudiesFemaleHumansMaleMiddle AgedProof of Concept StudyRatsCollagenCollagen Type I68GaCerebral aneurysmsCollagen tracerRadiotracerRupture riskSubarachnoid hemorrhage

Identifiers

PMID41557196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.