ArticleOncology and therapy2026
Characteristics, Treatment Patterns, and Outcomes of Patients with Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Analysis of Health Insurance Claims Data in Germany.
Article in Oncology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Single-Stoma Cutaneous Ureterostomy After Radical Cystectomy: A Contemporary Narrative Review.Current oncology (Toronto, Ont.) · 2026Review
- Perioperative Treatment Patterns for Muscle-Invasive Bladder Cancer Patients Undergoing Radical Cystectomy in the Adjuvant Immunotherapy Era: A Retrospective Analysis of US Community Oncology Practice.Oncology and therapy · 2026Article
- Urinary Extracellular Vesicles for High-Precision Bladder Cancer Subtyping and Prognosis.Journal of extracellular biology · 2026Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionMuscle-invasive bladder cancer (MIBC) is an aggressive form of bladder cancer characterized by high rates of metastasis and recurrence. Given recent advances in the treatment landscape, real-world evidence on current treatment patterns and outcomes remains limited, particularly outside of the USA. This study aimed to describe characteristics, treatment patterns, and outcomes of patients with MIBC undergoing radical cystectomy (RC) in a contemporary real-world setting in Germany.
methodsAdult patients with bladder cancer (BC) who underwent RC between October 2021 and June 2023 were identified from two German claims databases (AOK PLUS, GWQ). Patients with partial cystectomy, secondary malignant neoplasms, immunotherapies for metastatic disease prior to RC, radiotherapy, or in situ disease ≤ 6 months pre-RC were excluded. Patient characteristics and treatment patterns (neoadjuvant [NAT, ≤ 6 months pre-RC] and adjuvant periods [AT, ≤ 6 months post-RC]) were investigated in a descriptive analysis. Time to recurrence (from RC until end of follow-up [study period end: Dec 31, 2023]) was assessed as an exploratory outcome.
resultsThe study sample included 319 patients from AOK PLUS (n = 243 male patients, n = 76 female patients; mean age 71.4 ± 9.7 years) and 273 patients from GWQ (n = 227 male patients, n = 46 female patients; mean age 68.6 ± 10.1 years). Surgery without NAT/AT was the most common treatment (75.9% AOK, 74.0% GWQ). NAT and AT therapy utilization was low (NAT: 12.5% AOK, 17.2% GWQ; AT: 12.5% AOK, 12.1% GWQ; NAT and AT: 0.9% AOK, 3.3% GWQ). The most common adjuvant therapies received were chemotherapy (8.5% AOK, 7.0% GWQ) followed by immunotherapy/nivolumab (3.8% AOK, 4.8% GWQ), while < 2.5% received radiotherapy. The 12- and 24-month recurrence-free survival rates were 76.5% and 67.2% (AOK) and 73.7% and 69.6% (GWQ), respectively.
conclusionThe most prevalent treatment approach for MIBC was RC alone (in the absence of NAT or AT). The uptake of new therapeutic options, such as adjuvant nivolumab, in the real world was low, highlighting underutilization of available therapies.
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