Evidence map›Paper›PMID 41557135›Full record

ArticleRadiological physics and technology2026

Impact of the locking function of hybrid inverse planning optimization on the treatment plan quality of intracavitary/interstitial brachytherapy for locally advanced cervical cancer.

Tatsuya Inoue, Kotaro Iijima, Jun Takatsu, Naoya Murakami, Noriyuki Okonogi, Terufumi Kawamoto, Yasuo Kosugi, Yoichi Muramoto, Naoto Shikama

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Article in Radiological physics and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tatsuya InoueDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Kotaro IijimaDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. k.iijima.wt@juntendo.ac.jp.
Jun TakatsuDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Naoya MurakamiDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Noriyuki OkonogiDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Terufumi KawamotoDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yasuo KosugiDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yoichi MuramotoDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Naoto ShikamaDepartment of Radiation Oncology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the dosimetric characteristics of intracavitary/interstitial brachytherapy (IC/ISBT) plans created via the hybrid inverse planning optimization (HIPO) algorithm with the dwell time Lock function. MATERIALS AND

methodsSixteen patients with locally advanced cervical cancer treated with high-dose-rate IC/ISBT were evaluated. Based on the clinical plan data, five plans were retrospectively created: Manchester-based HIPO for needles, HIPO for all applicators, HIPO for needles after HIPO for tandem/ovoid, HIPO for ovoid after HIPO for tandem/needle, and HIPO for ovoid/needle after HIPO for tandem. The target coverage, organs at risk (OARs) doses, therapeutic ratios, and the dwell time contributions of the needles were analyzed to evaluate the plan quality. Dice similarity coefficients (DSCs) between clinical plan and each created plan were calculated to evaluate the similarity of the shape of the dose distribution.

resultsAll plans created using HIPO had a sufficient target coverage, while the OAR dose for the Manchester-based HIPO plans was considerably higher than the other plans. The plan with HIPO for all applicators and with HIPO for the ovoid applicator after HIPO for tandem/needles had comparable or superior therapeutic ratios than those of the clinical plan while the dwell time contributions of the needle were much larger. For DSCs, an intermediate to low correlation was observed between the clinical plan and all HIPO plans.

conclusionsThe HIPO algorithm could create high-quality IC/ISBT plans, although the dosimetric consequences were affected by the locking function.

Indexed as

BrachytherapyRadiotherapy Planning, Computer-AssistedUterine Cervical NeoplasmsAlgorithmsFemaleHumansOrgans at RiskQuality ControlRadiotherapy DosageRetrospective StudiesCervical cancerDice similarity coefficientHigh-dose-rate brachytherapyHybrid inverse planning optimizationIntracavitary/interstitial brachytherapyTherapeutic ratios

Identifiers

PMID41557135

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