Evidence map›Paper›PMID 41557120›Full record

ArticleVeterinary research communications2026

Expansion of host range for Streptococcus agalactiae: first case in hybrid marbled goby (Oxyeleotris marmoratus ♀ × Oxyeleotris lineolatus ♂) from aquaculture.

Wenhao Wu, Ruilong Xu, Yanxin Sun, Jiahao Zhang, Youlu Su, Biao Jiang

Abstract read
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In one paragraph

Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenhao Wu *Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong, China.
Ruilong Xu *Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong, China.
Yanxin SunFoshan Xijiang Biotechnology Co., Ltd, Foshan, 528220, Guangdong, China.
Jiahao ZhangGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong, China.
Youlu SuGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong, China. youlusu@zhku.edu.cn.
Biao JiangGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong, China. jiangbiao@zhku.edu.cn.

Funding

Guangdong Provincial Department of Science and Technology-Rural Science and Technology commissioner Project KTP20240408Modern Agricultural Research System Innovation Team Project of Guangdong Province 2024CXTD15
6 · The paper itself

Abstract

The hybrid marbled goby (Oxyeleotris marmoratus ♀ × Oxyeleotris lineolatus ♂) is a high-value aquaculture species in China, with rapidly increasing production in recent years. While Streptococcus agalactiae is a well-known pathogen in various fish species, its association with marbled goby has not been previously reported. Here, we present the first confirmed case of S. agalactiae infection in farmed hybrid marbled goby. Infected fish exhibited typical signs of streptococcosis, including erratic swimming, hemorrhages at fin bases, skin ulcers, and cloudy or hemorrhagic eyes. A Gram-positive bacterial strain, designated ZH2208, was isolated from diseased fish. Morphological, biochemical, 16 S rRNA sequencing, and phylogenetic analyses identified the isolate as S. agalactiae, serotype Ia-a dominant serotype previously associated with tilapia infections in Guangdong, China. Challenge experiments using doses of 1 × 10⁴ and 1 × 10⁷ CFU/fish confirmed the high virulence of ZH2208, resulting in 50% and 100% mortality, respectively. Eleven virulence genes involved in host invasion, hemolysis, immune evasion, and blood-brain barrier penetration were detected by PCR. Histopathology revealed typical lesions in gills, liver, spleen, kidney, and brain, including acute inflammation, hemorrhage, and neuronal degeneration. Notably, pronounced swim bladder swelling with distinct hemorrhagic spots was observed. Antibiotic susceptibility testing showed that ZH2208 was sensitive to enrofloxacin and doxycycline but resistant to several common aquaculture antibiotics, highlighting its multidrug-resistant profile. In conclusion, this study provides the first comprehensive characterization of S. agalactiae infection in hybrid marbled goby. These findings support the development of effective prevention and control strategies, including vaccination and rational antibiotic use, to manage streptococcal disease in goby aquaculture.

Indexed as

Fish DiseasesPerciformesStreptococcal InfectionsStreptococcus agalactiaeAnimalsAnti-Bacterial AgentsAquacultureChinaFemaleHost TropismPhylogenyRNA, Ribosomal, 16SVirulenceAnti-Bacterial AgentsRNA, Ribosomal, 16SAntibiotic resistanceHistopathologicalHybrid marbled gobyStreptococcus agalactiaeVirulence

Identifiers

PMID41557120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.