Evidence map›Paper›PMID 41557108›Full record

ArticleScience China. Life sciences2026

Disulfiram-induced c-FOS influences lipid metabolism and angiogenesis in hepatocellular carcinoma.

Zhuoran Qi, Xiuyan Kong, Jinlan Wu, Xiaojing Du, Matteo Jiang, Zhijie Yu, Xizhong Shen, Yuan Fang, Jinglin Xia

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhuoran Qi *Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xiuyan Kong *Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.
Jinlan Wu *Department of pediatrics, Jiading District Central Hospital, Shanghai, 201800, China.
Xiaojing Du *Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200032, China.
Matteo JiangLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhijie YuZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.
Xizhong ShenLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. shen.xizhong@zs-hospital.sh.cn.
Yuan FangDepartment of Liver Surgery, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. fangyuan1029@126.com.
Jinglin XiaLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. xiajinglin@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid metabolism disorders and increased angiogenesis play key roles in the tumorigenesis of hepatocellular carcinoma (HCC). Intracellular metal ion disorders such as cuproptosis and ferroptosis have been progressively identified. However, whether copper ions have other effects outside the already recognized mechanisms of cell death is just as worthy of investigation. In particular, the effects on lipid metabolism and angiogenesis have important roles in the development of HCC. Our study revealed that disulfiram (DSF), a copper ion carrier, not only had a significant antitumor effect in vitro and in vivo, but also significantly inhibited angiogenesis and reversed abnormal lipid metabolism. Through transcriptome analysis, m

Indexed as

Carcinoma, HepatocellularDisulfiramLipid MetabolismLiver NeoplasmsNeovascularization, PathologicProto-Oncogene Proteins c-fosAnimalsCell Line, TumorCopperGene Expression Regulation, NeoplasticHumansMethyltransferasesMiceCopperDisulfiramMethyltransferasesProto-Oncogene Proteins c-fosangiogenesishepatocellular carcinomalipid metabolismRNA modification

Identifiers

PMID41557108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.