ArticleVeterinary research communications2026
Evaluation of immunogenicity and protective efficacy of Salmonella Gallinarum knockout purB mutant strain in chicken.
Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel SG ΔpurB mutant of Salmonella Gallinarum, showed a strong safety profile as fowl typhoid vaccine candidate. In this study, the immunogenicity and protective efficacy of SG ΔpurB were evaluated following administration via intramuscular (Group A) and oral (Group B) at a dose range of 2 × 108 to 2 × 1010 CFU/200 µL. SG ΔpurB induced robust early humoral and cellular immune responses, with orally vaccinated subgroups B1, B2 and B3 eliciting markedly higher CD4 + T cell response, 45.5%, 46.9% and 36.4% respectively, than intramuscularly immunized birds A1, A2 and A3: 20.9%, 22.5% and 32.2% respectively. CD8 + T cell responses showed a similar trend B1, B2 and B3: 46.3%, 47.2% and 26.5%; A1, A2 and A3: 17.8%, 24.3% and 26.8% respectively. A comparable pattern was also observed for IFN-γ production and humoral IgG titre. Despite the strong initial responses, a gradual decline in immune responses was detected by 3 WPV, CD4 + and CD8 + T cell responses declined across all subgroups, with subgroups receiving higher doses (A2 and B3) retaining relatively elevated responses, underscoring the dose dependent nature of SG ΔpurB immunogenicity. These findings showed that SG ΔpurB is a safe and immunogenic strain, inducing a strong early immune response; however, further optimization, such as adding adjuvants or additional gene deletions, is needed for sustained and effective protection against fowl typhoid.
Indexed as
Identifiers
41557085What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.