Evidence map›Paper›PMID 41557079›Full record

ArticleMagma (New York, N.Y.)2026

Gadobenate dimeglumine-enhanced MRI at hepatobiliary phase can predict liver regeneration after partial hepatectomy in fibrotic rats.

Jiaying Bao, Yuanyuan Li, Gongzheng Wang, Pengyu Zhang, Jin Cui, Suhong Duan, Chengyong Qin, Min Huang, Xinya Zhao

Abstract read
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In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jiaying BaoDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Yuanyuan LiDepartment of Radiology, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China.
Gongzheng WangDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Pengyu ZhangDepartment of Anatomy, Jeonbuk National University Medical School, Jeonju, 54896, Republic of Korea.
Jin CuiDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Suhong DuanDepartment of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Chengyong QinDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Min Huang *Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwuweiqi Road, Jinan, 250021, Shandong, China. huangmin1983@aliyun.com.
Xinya Zhao *Department of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 16766 Jingshi Road, Jinan, 250021, Shandong, China. zhaoxinya2000@126.com.ORCID http://orcid.org/0000-0001-5856-347X

Funding

National Natural Science Foundation of China No. 82371916Taishan Scholar Foundation of Shandong Province NO. tsqn202312352
6 · The paper itself

Abstract

objectiveLiver regeneration after partial hepatectomy (PH) is markedly impaired in liver fibrosis, leading to serious complications. Non-invasive imaging methods for predicting regenerative capacity are crucial for preoperative planning and risk assessment. Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI at hepatobiliary phase has recently shown promise for assessing liver function. This study investigated the predictive value of Gd-BOPTA-enhanced MRI at hepatobiliary phase for liver regeneration in fibrotic rats. MATERIALS AND

methodsThirty male Sprague-Dawley rats with experimentally induced liver fibrosis underwent Gd-BOPTA-enhanced MRI. The relative enhancement ratios of liver parenchyma (REL) and biliary system (REB) were quantified during the hepatobiliary phase. After 70% PH, the liver regeneration rate (LRR) was calculated on day 3 and 5. Stepwise multivariable linear regression was conducted to identify imaging and biochemical determinants of LRR.

resultsIn fibrotic rats, the mean LRRs were 0.80 ± 0.10 (range, 0.64-1.01) and 1.06 ± 0.09 (range, 0.89-1.17) on day 3 and 5 after PH, respectively. Multivariable analysis identified REL (p = 0.002), REB (p = 0.026), and alanine aminotransferase (ALT; p = 0.040) as the strongest determinants of LRR on day 3 (Predicted LRR on day 3 = 0.368 + 1.332 × REL + 0.105 × REB - 0.001 × ALT(IU/l)). On day 5, REL (p < 0.001) and REB (p = 0.023) remained significant determinants of LRR (Predicted LRR on day 5 = 1.107 + 2.601 × REL - 0.173 × REB). DISCUSSION: Gd-BOPTA-enhanced MRI at hepatobiliary phase can effectively predict LRR on day 3 and 5 after partial hepatectomy in fibrotic rats.

Indexed as

HepatectomyLiver CirrhosisLiver RegenerationMagnetic Resonance ImagingMeglumineOrganometallic CompoundsAnimalsContrast MediaLiverMaleRatsRats, Sprague-DawleyContrast Mediagadobenic acidMeglumineOrganometallic CompoundsFibrosisGadobenate dimeglumineHepatectomyLiver regenerationMagnetic resonance imaging

Identifiers

PMID41557079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.