Evidence map›Paper›PMID 41557043›Full record

ArticlePurinergic signalling2026

Abnormal purinergic signaling contributes to development of renal cysts in autosomal dominant polycystic kidney disease.

Veniamin Ivanov, Andrew Wu, Letizia Crocetti, Ze Meng, Puja Shrestha-Maskey, Tang-Dong Liao, Indra Adrianto, Gabriella Guerrini, Pablo A Ortiz, Tengis S Pavlov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Veniamin IvanovDivision of Hypertension and Vascular Research, Department of Medicine, Henry Ford Health, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Andrew WuDivision of Hypertension and Vascular Research, Department of Medicine, Henry Ford Health, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Letizia CrocettiDepartment of Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy.
Ze MengDepartment of Public Health Sciences, Henry Ford Health, 1 Ford Pl, Detroit, MI, 48202, USA.
Puja Shrestha-MaskeyDivision of Hypertension and Vascular Research, Department of Medicine, Henry Ford Health, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Tang-Dong LiaoDivision of Hypertension and Vascular Research, Department of Medicine, Henry Ford Health, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Indra AdriantoDepartment of Public Health Sciences, Henry Ford Health, 1 Ford Pl, Detroit, MI, 48202, USA.
Gabriella GuerriniDepartment of Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy.
Pablo A OrtizDivision of Hypertension and Vascular Research, Department of Medicine, Henry Ford Health, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Tengis S PavlovDivision of Hypertension and Vascular Research, Department of Medicine, Henry Ford Health, 6135 Woodward Ave, Detroit, MI, 48202, USA. Tpavlov1@hfhs.org.

Funding

Regulation of NKCC2 and renal NaCl transport by protein-protein interactionsR01DK131114 · NIDDK · WAYNE STATE UNIVERSITY · PI Pablo A. Ortiz · 2023 to 2026
$2.2M
Pannexin-1/P2X7 interaction promotes excessive ATP release in kidney cysts and ADPKD progression via reduced NaCl reabsorptionR01DK123266 · NIDDK · WAYNE STATE UNIVERSITY · PI PAVLOV, TENGIS S · 2021 to 2024
$1.6M
Regulation of NKCC2 and renal NaCl transport by protein-protein interactionsR56DK131114 · NIDDK · WAYNE STATE UNIVERSITY · PI ORTIZ, PABLO A. · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK123266NIDDK NIH HHS R01 DK131114NIDDK NIH HHS R56 DK131114NIH HHS DK123266NIH HHS DK131114
6 · The paper itself

Abstract

Polycystic kidney diseases (PKD) are a group of inherited nephropathies marked by the formation of fluid-filled cysts along the nephron, which cause renal failure. Bulk RNA sequencing of microdissected renal cysts from Pkd1

Indexed as

CystsPolycystic Kidney, Autosomal DominantReceptors, PurinergicSignal TransductionAdenosine TriphosphateAnimalsConnexinsMiceAdenosine TriphosphateConnexinsReceptors, PurinergicATPPannexinPolycystic kidney diseasesPurinergic signaling

Identifiers

PMID41557043
PMCPMC12819920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.