Risk of preterm birth and peripartal complications after first trimester termination of pregnancy: a retrospective cohort study of 35,897 singleton births.

Caroline Helena Gabrysch, Livia Schirru, Wolfgang Henrich, Silke Wegener

Abstract read

In one paragraph

Article in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Artificial Intelligence and Machine Learning for predicting Major Obstetric Emergencies: Current Evidence, Clinical Translation, and Future Directions.International journal of women's health · 2026
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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Caroline Helena GabryschDepartment of Obstetrics, Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Livia SchirruDepartment of Obstetrics, Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Wolfgang HenrichDepartment of Obstetrics, Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Silke WegenerDepartment of Obstetrics, Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany. silke.wegener@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this study was to explore whether a history of termination of pregnancy (TOP) in births after 2015 in a high income setting is still linked to preterm birth (PTB) and peripartal complications.

methods35,897 singleton births from a perinatal center with approximately 5000 births per year between 2015 and 2022 were analyzed. Patients with a history of first trimester TOP (TOP < 15 weeks) were compared to those who had never had a TOP. A two-step statistical approach using Chi-squared analysis and forward-step multiple logistic regression was used to explore the relationship.

results4132 individuals (11.51%) had a history of first trimester TOP. Our findings suggest an association between past TOP and a higher risk for PTB (OR = 1.44, 95% CI [1.25-1.67], p < 0.001). This increases with the number of TOP, six or more TOP were associated with the highest odds ratio for spontaneous PTB (OR = 5.21, 95% CI [1.88-14.46], p = 0.002). The risk for PTB did not differ between methods. Furthermore, our data suggest an association between past TOP and placental retention (OR = 1.25, 95% CI [1.03-1.52],p = 0.022).

conclusionThese findings underscore the importance of still recognizing prior TOP as a risk factor in obstetric care. The results may inform targeted counseling and the development of preventative strategies to mitigate maternal and fetal morbidity.

Indexed as

Abortion, InducedPremature BirthAdultFemaleHumansInfant, NewbornLogistic ModelsPregnancyPregnancy Trimester, FirstRetrospective StudiesRisk FactorsPeripartal hemorraghePreterm birthReproductive counselingTermination of pregnancy

Identifiers

PMID41557012

DOI10.1007/s00404-025-08242-w

PMCPMC12819516

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