Evidence map›Paper›PMID 41556979›Full record

ArticleJournal of behavioral addictions2026

Connectome-based predictive modelling of problematic gaming in youth from the ABCD study.

Jennifer J Park, Cheryl M Lacadie, Dustin Scheinost, Li Yan McCurdy, Marc N Potenza, Yihong Zhao

Abstract read
In one paragraph

Article in Journal of behavioral addictions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer J Park1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-7988-4704
Cheryl M Lacadie2Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0009-0006-3130-4156
Dustin Scheinost2Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-6301-1167
Li Yan McCurdy1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-8862-6715
Marc N Potenza1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-6323-1354
Yihong Zhao8Columbia University School of Nursing, New York, NY, USA.ORCID https://orcid.org/0000-0001-8730-0476

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite the rapid growth in gaming consumption and associated harms in adolescents, data-driven research to identify brain networks underlying problematic gaming remains limited. This study aimed to identify neural networks predictive of problematic-gaming severity in youth using connectome-based predictive modelling (CPM), a machine-learning approach that employs whole-brain functional connectivity data. Methods: From the Adolescent Brain Cognitive Development study at the two-year follow-up, 1,036 participants (Mage = 12.0, 60.7% male) were studied. CPM with 10-fold cross-validation was applied to problematic-gaming scores and functional magnetic resonance imaging (fMRI) data collected during the performance of a reward-processing task. To determine generalizability, additional CPM analyses were performed using other task-based (e.g., those relevant to response inhibition, emotion regulation, and working memory) and resting-state fMRI data. Results: CPM successfully predicted problematic-gaming scores (r = 0.12, p = 0.002). Predictive networks involved several connections within and between canonical networks implicated in visual processing (visual area 2 and visual association networks), cognitive control and executive functioning (frontoparietal and medial frontal networks), and relevance and motor response (salience and sensorimotor networks). CPM predicted problematic-gaming scores across all analyzed brain states and found shared predictive canonical networks, indicating generalizability. Applying the final reward-processing model to other task-based and resting-state fMRI data also successfully predicted problematic-gaming severity. Conclusions: The identified large-scale networks predictive of problematic-gaming severity in adolescents may serve as promising targets for personalized and novel interventions. Before using these results to guide clinical advances, future research should use external samples to evaluate replicability of the identified network.

Indexed as

Adolescent BehaviorBrainConnectomeInternet Addiction DisorderNerve NetVideo GamesAdolescentChildFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMalePredictive Learning ModelsRewardaddictive behaviorscompulsive behaviorsfunctional magnetic resonance imaginginternet addictionvideo gamesyouth

Identifiers

PMID41556979
PMCPMC13132421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.