Observational studyJournal of acquired immune deficiency syndromes (1999)2026
Anxiety Symptom Ratings Before and During the Interruption of Antiretroviral Therapy as Part of HIV Cure-related Studies.
Observational study in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combinatorial Therapy With a Therapeutic Conserved Element DNA Vaccine, MVA Vaccine Boost, TLR9 Agonist and Broadly Neutralizing Antibodies: a Proof-of-concept Study Aimed at Inducing an HIV Remission
Analytic Treatment Interruption in HIV Infection
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7 authors.
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Abstract
backgroundAn analytical treatment interruption (ATI) is a critical component of HIV cure research, allowing researchers to assess potential strategies aimed at durable antiretroviral treatment-free viral control. However, pausing antiretroviral treatment during an ATI may lead to uncertainty and psychological distress. Limited empirical data exist on the mental health impact of an ATI, specifically anxiety symptoms.
methodsWe conducted a longitudinal study to assess self-reported anxiety levels before and during an ATI in two HIV cure-related research studies at the University of California, San Francisco. Study 1 was an observational ATI study (NCT04359186), whereas study 2 was an interventional HIV cure trial (NCT04357821). Anxiety was measured at multiple time points using the Generalized Anxiety Disorder-7 and the State-Trait Anxiety Inventory. We analyzed changes in anxiety scores over time using interrupted time-series models.
resultsIn study 1, anxiety was elevated at baseline and gradually declined over time but remained within the mild severity range. In study 2, anxiety increased significantly from before the ATI and during ATI, with higher peak anxiety levels compared with study 1. Anxiety was highly prevalent in both studies and increased during the ATI in study 2.
conclusionsThe uncertainty with an ATI may contribute to increased mild anxiety. However, this uncertainty can be measured and with resources, easily addressed to reduce risks for psychological harm.
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Registered trials
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