ArticleeLife2026
Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).
Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- eFEL: electrophysiology feature extraction library.Bioinformatics (Oxford, England) · 2026Article
- Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex.PLoS computational biology · 2026Article
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- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
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- A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers.PLoS computational biology · 2025Article
- A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations.Network neuroscience (Cambridge, Mass.) · 2025Article
- What makes human cortical pyramidal neurons functionally complex.bioRxiv : the preprint server for biology · 2024Article
- Specific inhibition and disinhibition in the higher-order structure of a cortical connectome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Cortical cell assemblies and their underlying connectivity: An in silico study.PLoS computational biology · 2024Article
- Enhancement of brain atlases with laminar coordinate systems: Flatmaps and barrel column annotations.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Controlling morpho-electrophysiological variability of neurons with detailed biophysical models.iScience · 2023Article
Corrections and comments
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Authors and funding
42 authors.
Funding
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Abstract
Cortical dynamics underlie many cognitive processes and emerge from complex multiscale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool that can complement laboratory approaches. We present a model comprising eight somatosensory cortex subregions, 4.2 million morphological and electrically detailed neurons, and 13.2 billion local and mid-range synapses. In silico tools enabled reproduction and extension of complex laboratory experiments under a single parameterization, providing strong validation. The model reproduced millisecond-precise stimulus-responses, stimulus-encoding under targeted optogenetic activation, and selective propagation of stimulus-evoked activity to downstream areas. The model's direct correspondence with biology generated predictions about how multiscale organization shapes activity; for example, how cortical activity is shaped by high-dimensional connectivity motifs in local and mid-range connectivity, and spatial targeting rules by inhibitory subpopulations. The latter was facilitated using a rewired connectome that included specific targeting rules observed for different inhibitory neuron types in electron microscopy. The model also predicted the role of inhibitory interneuron types and different layers in stimulus encoding. Simulation tools and a large subvolume of the model are made available to enable further community-driven improvement, validation, and investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.