ArticleeLife2026
Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy).
Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex.PLoS computational biology · 2026Article
- A multimodal spatial atlas of transcriptomic, morphological, and electrophysiological cell type densities in the mouse brain.PLoS computational biology · 2026Article
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
- Learning to combine top-down context and feed-forward representations under ambiguity with apical and basal dendrites.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers.PLoS computational biology · 2025Article
- BlueRecording: A pipeline for the efficient calculation of extracellular recordings in large-scale neural circuit models.PLoS computational biology · 2025Article
- Heterogeneous and higher-order cortical connectivity undergirds efficient, robust, and reliable neural codes.iScience · 2025Article
- Computational Generation of Long-range Axonal Morphologies.Neuroinformatics · 2025Article
- A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations.Network neuroscience (Cambridge, Mass.) · 2025Article
- What makes human cortical pyramidal neurons functionally complex.bioRxiv : the preprint server for biology · 2024Article
- Specific inhibition and disinhibition in the higher-order structure of a cortical connectome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Reconciliation of weak pairwise spike-train correlations and highly coherent local field potentials across space.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
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Authors and funding
43 authors.
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Abstract
The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, interregional connectivity. We present a data-driven computational model of the anatomy of non-barrel primary somatosensory cortex of juvenile rat, integrating whole-brain scale data while providing cellular and subcellular specificity. The model consists of 4.2 million morphologically detailed neurons, placed in a digital brain atlas. They are connected by 14.2 billion synapses, comprising local, mid-range and extrinsic connectivity. We delineated the limits of determining connectivity from neuron morphology and placement, finding that it reproduces targeting by Sst+ neurons, but requires additional specificity to reproduce targeting by PV+ and VIP+ interneurons. Globally, connectivity was characterized by local clusters tied together through hub neurons in layer 5, demonstrating how local and interegional connectivity are complicit, inseparable networks. The model is suitable for simulation-based studies, and the model is made openly available to the community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.