Evidence map›Paper›PMID 41556657›Full record

ArticlemBio2026

Targeting the lung innate pathways during tuberculosis can improve vaccine-induced protection via Th17 responses in diversity outbred mice.

Mushtaq Ahmed, Shibali Das, Bruce A Rosa, Javier Rangel Moreno, Deepak Kaushal, Makedonka Mitreva, Shabaana A Khader

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. HowVaccines · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mushtaq AhmedDepartment of Microbiology, The University of Chicago, Chicago, Illinois, USA.ORCID 0009-0005-0231-6898
Shibali DasDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Bruce A RosaDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
Javier Rangel MorenoDepartment of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA.
Deepak KaushalSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.ORCID 0000-0003-3521-1257
Makedonka MitrevaDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0001-9572-3436
Shabaana A KhaderDepartment of Microbiology, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9545-4982

Funding

ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
ROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9M
A Novel Th17-inducing Mucosal Vaccine for TuberculosisR01AI150043 · NIAID · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2020 to 2023
$3.4M
COMMON IMMUNE CORRELATES OF RISK OF TB DISEASE IN ANIMAL MODELS AND HUMANSR01AI123780 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2016 to 2019
$2.9M
NHLBI NIH HHS R01 HL105427NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI123780NIAID NIH HHS R01 AI150043
6 · The paper itself

Abstract

Tuberculosis (TB), caused by the bacterium IMPORTANCE: Bacille Calmette Guerin (BCG) vaccination in genetically diverse outbred (DO) mice provides significant protection against

Indexed as

BCG VaccineImmunity, InnateLungTh17 CellsTuberculosisTuberculosis VaccinesAnimalsDisease Models, AnimalFemaleMiceMycobacterium tuberculosisSignal TransductionBCG VaccineTuberculosis VaccinesMycobacterium tuberculosisTh17 cellsvaccines

Identifiers

PMID41556657
PMCPMC12893010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.