Evidence map›Paper›PMID 41556638›Full record

ArticleMovement disorders clinical practice2026

Capturing Behavioral Symptoms in Huntington's Disease Using the Huntington's Disease-Behavioral Questionnaire.

Siena Rigatuso, Krisha Bagga, Shelby Hughes, Japleen Kaur, Paul E Gilbert, Jody Corey-Bloom

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Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Siena RigatusoDepartment of Neurosciences, University of California, San Diego, San Diego, California, USA.ORCID https://orcid.org/0009-0003-1557-0516
Krisha BaggaDepartment of Neurosciences, University of California, San Diego, San Diego, California, USA.ORCID https://orcid.org/0009-0006-6438-1844
Shelby HughesDepartment of Neurosciences, University of California, San Diego, San Diego, California, USA.
Japleen KaurDepartment of Neurosciences, University of California, San Diego, San Diego, California, USA.ORCID https://orcid.org/0009-0006-6553-0944
Paul E GilbertDepartment of Psychology, San Diego State University, San Diego, California, USA.
Jody Corey-BloomDepartment of Neurosciences, University of California, San Diego, San Diego, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Huntington's Disease Behavioral Questionnaire (HD-BQ) captures behavioral symptoms arising from cognitive, psychiatric, and functional domains. Recognizing the high prevalence of anosognosia in HD, the HD-BQ incorporates patient- and companion-reported versions.

objectiveExamine the utility of the HD-BQ in capturing behavioral symptoms in HD.

methodsThe HD-BQ was administered to 71 manifest HD patients and their companions, plus 71 healthy controls (HC). Differences in HD-BQ scores were examined using Mann-Whitney U and Wilcoxon signed-ranks tests.

resultsHD patients reported more severe behavioral symptoms than HC (p < 0.001). Companions reported more widespread and severe symptoms than patients (Z = -3.7, p < 0.001). The largest discrepancies were observed for cognitive items-difficulty shifting thoughts or activities (p < 0.001), concentrating (p = 0.002), keeping track of commitments (p = 0.006), judgment (p = 0.004), and indecisiveness (p = 0.022).

conclusionsThe HD-BQ captures a wide range of behavioral disturbances in HD. Companions consistently reported more frequent and severe symptoms than patients, likely reflecting patients' anosognosia.

Indexed as

Behavioral SymptomsHuntington DiseaseAdultAgedAgnosiaFemaleHumansMaleMiddle AgedSurveys and Questionnairesanosognosiabehavioral symptomsdual‐informant assessmentHuntington's disease

Identifiers

PMID41556638
PMCPMC13306907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.