ArticleMacromolecular bioscience2026
Calcium Phosphate Mineralization of Bulk Alginate Hydrogels Composites With Metal and Metal Oxide Nanoparticles.
Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Calcium Phosphate Mineralization of Bulk Alginate Hydrogels Composites With Metal and Metal Oxide Nanoparticles.Macromolecular bioscience · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Alginate hydrogels are promising materials for biomedical applications due to their biocompatibility and ability to mimic the extracellular matrix. However, poor mechanical stability and limited bioactivity hinder their wider clinical application. This problem can be overcome by incorporating nanoparticles (NPs) and calcium phosphates (CaPs). In this study, the simultaneous gelation and CaP mineralization of bulk alginate hydrogels in the presence of antimicrobial silver (AgNP), copper oxide (CuONP), and zinc oxide (ZnONP) was investigated. Calcium-deficient hydroxyapatite forms at pH 7.4, and stable amorphous calcium phosphate at pH 9.0. The incorporation of NPs influences the morphology of mineral phases but not composition. Rheological testing revealed that mineralized hydrogels exhibit earlier network breakdown compared to the non-mineralized ones, with critical strain values dependent on both pH and NP type. Ion release is pH-dependent, with generally higher metal ion release from non-mineralized hydrogels. Antibacterial assays demonstrate significant inhibition of S. aureus by hydrogels prepared at pH 9.0, except for hydrogels containing CuONPs. For P. aeruginosa, the differences in inhibition rates between different hydrogels were less pronounced. The obtained results indicate that CaP-mineralized alginate hydrogels incorporating metal and metal oxide NPs exhibit tunable properties, confirming their potential for bone tissue engineering applications and infection prevention.
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