Evidence map›Paper›PMID 41556614›Full record

ReviewAsian journal of andrology2026

A narrative review on the role of autophagy in male infertility-associated sperm abnormalities.

Yi-Han Jin, Da-Wei Gao, Chu-Yu Li, Da-Lin Sun, Hui Mo, Bao-Fang Jin

Abstract readReview
In one paragraph

Review in Asian journal of andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi-Han JinFaculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Da-Wei GaoFaculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Chu-Yu LiFaculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Da-Lin SunAndrology Department of Integrative Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.
Hui MoFaculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Bao-Fang JinAndrology Department of Integrative Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility is one of the most prevalent disorders affecting the male reproductive system, with the majority of cases originating from sperm abnormalities. Autophagy, a highly conserved cellular process, plays critical roles in spermatogenesis, sperm maturation, and functional maintenance. Aberrant autophagic activity is closely associated with various sperm abnormalities, including oligozoospermia, asthenozoospermia, teratozoospermia, and azoospermia. In this narrative review, we provide a comprehensive overview of the current knowledge on the role of autophagy in sperm abnormality-related male infertility, detailing the relationship between autophagic dysfunction and various sperm disorders. We compile and synthesize findings from major clinical studies, basic science research, and relevant reviews to highlight the role of autophagy and its therapeutic potential. These insights may contribute to advancing the clinical management of male infertility through the identification of novel therapeutic targets related to autophagic regulation.

Indexed as

AutophagyInfertility, MaleSpermatozoaAnimalsAsthenozoospermiaAzoospermiaHumansMaleOligospermiaSpermatogenesisTeratozoospermiaautophagymale infertilitysperm abnormalityspermatogenesis

Identifiers

PMID41556614
PMCPMC13423387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.