Evidence map›Paper›PMID 41556458›Full record

Trial reportClinical cardiology2026

The Effect of Age on Improvement in Health-Related Quality of Life After Percutaneous Coronary Intervention.

Laura Lappalainen, Piia Lavikainen, Risto P Roine, Harri Sintonen, Janne Martikainen, Anna-Maija Tolppanen, Juha Hartikainen

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura LappalainenKuopio University Hospital, Kuopio, Finland.ORCID https://orcid.org/0000-0002-1532-0600
Piia LavikainenUniversity of Eastern Finland, Kuopio, Finland.
Risto P RoineUniversity of Helsinki, Helsinki, Finland and Kuopio University Hospital, Kuopio, Finland.
Harri SintonenUniversity of Helsinki, Helsinki, Finland.
Janne MartikainenKuopio University Hospital, Kuopio, Finland and University of Eastern Finland, Kuopio, Finland.
Anna-Maija TolppanenUniversity of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0001-9270-9268
Juha HartikainenKuopio University Hospital, Kuopio, Finland and University of Eastern Finland, Kuopio, Finland.

Funding

Northern-Savo Cultural FoundationResearch Foundation of Kuopio University HospitalState Research Fund of Kuopio University Hospital, Finland, and the Research Council of Finland
6 · The paper itself

Abstract

introductionPercutaneous coronary intervention (PCI) is the first-line therapy in patients scheduled for coronary revascularization, aiming to relieve symptoms of coronary artery disease (CAD) and improve health-related quality of life (HRQoL) and prognosis. Particularly, in older adults, symptom alleviation and HRQoL are emphasized. However, it is not known whether older patients benefit from PCI equally to their younger peers. We used disease-specific and generic instruments to evaluate the improvement in HRQoL after PCI, comparing changes in three age groups.

methodsAltogether 300 patients undergoing PCI were divided into three age groups: ≥ 75 years (n = 89), 66-74 years (n = 117), and ≤ 65 years (n = 94). HRQoL was measured using the disease-specific Seattle Angina Questionnaire (SAQ-7) and the generic 15D instrument at baseline, one, and 12 months.

resultsStatistically and clinically significant improvements in the SAQ-7 and 15D scores were observed after one- and 12-month follow-up in all age groups. There were no differences in the 12-month improvements in the SAQ-7 and 15D scores between the groups. The 15D score started to decline after 1 month, particularly in the oldest group. The decline was associated with age-related rather than CAD-related 15D dimensions.

conclusionsOur findings on comparable improvement in disease-specific and generic HRQoL after PCI in older and younger patients are encouraging, particularly considering that the aims of PCI in older adults are predominantly symptom alleviation and improvement of daily activities. In addition, to overcome age-related changes in HRQoL, a disease-specific instrument should be incorporated in the evaluation of PCI on HRQoL. CLINICAL

trial registration5101114.

Indexed as

Coronary Artery DiseasePercutaneous Coronary InterventionQuality of LifeAgedAged, 80 and overAge FactorsFemaleFollow-Up StudiesHumansMaleMiddle AgedSurveys and QuestionnairesTime FactorsTreatment Outcomecoronary artery diseasehealth‐related quality of lifepatient‐reported outcomesPercutaneous coronary intervention

Identifiers

PMID41556458
PMCPMC12817284

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.