Evidence map›Paper›PMID 41556369›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DEL-1 is an Endogenous Senolytic Protein that Inhibits Senescence-Associated Bone Loss.

Jong-Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung-Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D C Surboyo, Tomoki Maekawa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jong-Hyung LimDepartment of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-9644-5359
Kridtapat SirisereephapCenter for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8514, Japan.
Hui WangDepartment of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Giulia TrimaglioInstitute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Kyoung-Jin ChungInstitute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
Jonathan KorostoffDepartment of Periodontics, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tetsuhiro KajikawaDepartment of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xiaofei LiDepartment of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Meircurius D C SurboyoCenter for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8514, Japan.
Tomoki MaekawaCenter for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8514, Japan.
Triantafyllos ChavakisInstitute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, 01307, Dresden, Germany.
George HajishengallisDepartment of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0001-7392-8852

Funding

Local endogenous regulators of functional immune plasticity in the periodontiumR37DE026152 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2016 to 2025
$3.5M
IL-22, Immune Plasticity, and Autotherapy in the PeriodontiumR01DE029436 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2020 to 2024
$1.9M
Aging and dysfunction of progenitor niches: Role of Del-1R01DE028561 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2020 to 2024
$1.7M
Deutsche Forschungsgemeinschaft, Collaborative Research Centre TRR369, projectC03 3493/1-1Japan Agency for Medical Research and Development JP23ym0126801Japan Agency for Medical Research and Development JP24ym0126801Japan Society for the Promotion of Science 23K24525Japan Society for the Promotion of Science 23KK0160Mochida Memorial Foundation for Medical and Pharmaceutical Research J23G0194NIDCR NIH HHS DE026152NIDCR NIH HHS DE028561NIDCR NIH HHS DE029436NIDCR NIH HHS R01 DE028561NIDCR NIH HHS R01 DE029436NIDCR NIH HHS R37 DE026152the German Center for Child and Adolescent Health
6 · The paper itself

Abstract

Accumulation of senescent cells in the bone microenvironment, including bone marrow mesenchymal stromal cells (BM-MSCs), contributes to aging-related bone degeneration. Developmental endothelial locus-1 (DEL-1), the expression of which declines with old age is herein described as an endogenous secreted senolytic protein. DEL-1 promotes apoptosis of senescent BM-MSCs via a β3 integrin/CD73/adenosine/p38 mitogen-activated protein kinase (p38 MAPK)/B-cell lymphoma-2 (BCL-2) pathway, thereby leading to their clearance by macrophages. DEL-1-deficiency displays increased abundance of β3 integrin-rich CD73

Indexed as

Acid Anhydride HydrolasesAgingCalcium-Binding ProteinsCarrier ProteinsCellular SenescenceMesenchymal Stem CellsAnimalsApoptosisCell Adhesion MoleculesHumansMiceAcid Anhydride HydrolasesCalcium-Binding ProteinsCarrier ProteinsCell Adhesion MoleculesEDIL3 protein, humanEdil3 protein, mouseagingbone lossbone marrow mesenchymal stromal cellsdevelopmental endothelial locus‐1senescencesenolytics

Identifiers

PMID41556369
PMCPMC12948198

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.