Evidence map›Paper›PMID 41556325›Full record

ArticleHuman vaccines & immunotherapeutics2026

Impact of two-dose varicella vaccination in Guangzhou: An interrupted time-series study.

Huan Zhang, Yanhui Liu, Xing Ye, Lei Luo, Qing He

Abstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huan ZhangDepartment of Communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Yanhui LiuDepartment of Communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Xing YeDepartment of Communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Lei LuoDepartment of Communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Qing HeDepartment of Communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.ORCID 0000-0002-3588-9466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In November 2017, Guangzhou implemented a self-paid two-dose varicella vaccination program. This study evaluated the program's impact on varicella incidence trends across the general population and specific age groups. An interrupted time-series analysis was conducted using surveillance data from January 2011 to December 2024. The pre-intervention period spanned 2011-2017, and the post-intervention period 2018-2024. Seasonal-trend decomposition and segmented regression were employed to analyze changes in level and trend of varicella incidence. A total of 225,497 varicella cases were reported between 2011 and 2024. The annual incidence rate decreased by 28.1% from the pre-intervention to post-intervention period, from 126.80 to 91.14 per 100,000 population. Prior to intervention, there was no evidence of a monthly change in varicella incidence (0.3%; t = 2.27,

Indexed as

ChickenpoxChickenpox VaccineImmunization ProgramsPopulation SurveillanceVaccinationAdolescentAdultChildChild, PreschoolChinaFemaleHumansImmunization ScheduleIncidenceInfantInfant, NewbornChickenpox Vaccineinterrupted time seriesvaccination strategyVaricella

Identifiers

PMID41556325
PMCPMC12826739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.