Evidence map›Paper›PMID 41556285›Full record

ArticleBrain injury2026

miR-26b-5p responds to aerobic exercise intervention for concussion recovery in adolescent athletes: a pilot trial.

Haley Chizuk, Jeffrey C Miecznikowski, Alex Rawlings, Jaffer Sayeed, Mohammad Nadir Haider, John Leddy, Praveen Arany

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain injury, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haley ChizukUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.
Jeffrey C MiecznikowskiDepartment of Biostatistics, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, New York.
Alex RawlingsUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.
Jaffer SayeedUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.
Mohammad Nadir HaiderUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.
John LeddyUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.
Praveen AranyDepartment of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York.

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
NCATS NIH HHS UL1 TR001412
6 · The paper itself

Abstract

backgroundGuidelines for sport-related concussion (SRC) management recommend aerobic exercise treatment. Salivary microRNAs (miRNAs) associate with exercise and concussion; therefore, we investigated their expression in adolescents with SRC during prescribed exercise.

methodsBefore and after intervention, athletes with SRC (

resultsmiRNAs 1246, 944, 151a-3p, and 26b-5p were reduced (

conclusionmiRNAs 1246, 944, and 151a-3p may be concussion biomarkers unaffected by aerobic exercise. miR-26b-5p, associated with concussion and exercise volume, may be a useful biomarker to monitor adherence to exercise prescriptions for SRC recovery.

Indexed as

Athletic InjuriesBrain ConcussionExerciseExercise TherapyMicroRNAsRecovery of FunctionAdolescentAthletesFemaleHumansMalePilot ProjectsSalivaMicroRNAsMIRN26 microRNA, humanadolescentathletebiomarkerConcussionexercisemicroRNA

Identifiers

PMID41556285
PMCPMC12890018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.