Trial reportJournal of the International Society of Sports Nutrition2026
Whey protein intakes up to 0.4g/kg body mass are well tolerated before a 10km run at 85% of race pace: a clinical trial.
Trial report in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Microbiota-mediated gut-brain communication following whey protein supplementation and resistance training: current evidence linking gastrointestinal function and cognitive health.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExercise induced gastrointestinal (GI) symptoms affect a significant portion of endurance runners, resulting in discomfort and suboptimal performance. Protein intakes pre-exercise may have benefits; however, research investigating dietary intake prior to exercise suggests that many runners avoid foods high in protein before running to manage their GI symptoms. Unfortunately, clinical trials evaluating the effectiveness of this strategy are lacking. This study aimed to quantify exercise-induced GI symptoms, gut fullness, blood glucose response, and ratings of perceived exertion in response to low-protein (LP) and moderate-protein (MP) pre-exercise shake.
methodsThis single-blind crossover study involved 13 recreational runners (eight females, five males) who completed a 10 km treadmill run at 85% of their 10 km race pace after consuming a shake with carbohydrate and whey protein at either a low-protein (0.15 g/kg body mass) or moderate-protein (0.4 g/kg body mass) dose 60 minutes prior to exercise. Due to increased whey protein and standardized carbohydrate, the shakes had differing energy contents. GI symptoms were assessed pre-shake, 60 minutes post-shake, and post-run using a questionnaire and gut fullness was assessed pre-shake, 15-, 30-, and 60 minutes post-shake, and post-run using a visual analog scale. Blood glucose was measured pre-shake, 30- and 60 minutes post-shake, and post-run using a capillary blood sample and rating of perceived exertion was assessed following the 10 km run.
resultsTotal symptoms experienced increased over time (
conclusionsEasily digestible protein sources up to 0.4 g/kg body mass consumed one hour before exercise are advised and generally well tolerated, though 0.4 g/kg body mass of protein was associated with increased bloating. However, protein intakes before exercise should be trialed prior to competition due to variations in individual tolerance.
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Registered trials
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