Evidence map›Paper›PMID 41556085›Full record

ArticleMicrobiologyOpen2026

Septic Shock Caused by Coinfection of Shewanella algae Bloodstream Infection and Epstein-Barr Virus: Clinical Characteristics and Genomic Analysis.

Jianmei Chen, Dong Ling, Feng Wang, Liping Liu, Yucheng Ren, Chengying Chen, Na Su

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianmei ChenDepartment of Clinical Laboratory, Chongzhou People's Hospital, Chongzhou, China.ORCID 0009-0005-8610-5042
Dong LingDepartment of Clinical Laboratory, Chongzhou People's Hospital, Chongzhou, China.
Feng WangDepartment of Clinical Laboratory, Chongzhou People's Hospital, Chongzhou, China.
Liping LiuDepartment of Clinical Laboratory, Chongzhou People's Hospital, Chongzhou, China.
Yucheng RenDepartment of Clinical Laboratory, Chongzhou People's Hospital, Chongzhou, China.
Chengying ChenDepartment of Clinical Laboratory, Chongzhou People's Hospital, Chongzhou, China.
Na SuDepartment of Oncology and Hematology, Chongzhou People's Hospital, Chongzhou, China.

Funding

Chengdu Medical Research Project 2023170Youth Innovation Medical Research Project of Chongzhou People's Hospital 2024001Youth Innovation Project of Sichuan Medical Association Q22080
6 · The paper itself

Abstract

Shewanella algae, a marine-origin opportunistic pathogen, has shown a significant increase in non-coastal infections, yet its environmental adaptability and synergistic pathogenic mechanisms with Epstein-Barr virus (EBV) coinfection remain unclear. This study reports a clinical case of S. algae bloodstream infection complicated by EBV reactivation leading to septic shock in Sichuan Province, China, and elucidates the molecular mechanisms through genomic analysis. Pathogen identification was performed via blood culture, antibiotic susceptibility testing, and genomic annotation. The strain harbored resistance genes (acrB, tolC, tet(35), golS) and virulence factors (bplL/bplF, clpC/clpP, tonB). Phylogenetic analysis indicated the highest genetic affinity to freshwater-derived Shewanella chilikensis, while pan-genome analysis identified 1412 unique genes, including transmembrane transporters and carbohydrate-active enzyme genes, suggesting freshwater adaptive evolution. Metagenomic next-generation sequencing (mNGS) detected a high EBV load. The patient succumbed to multi-organ failure. This study reveals that S. algae may evolve freshwater adaptability to cause inland infections, and EBV coinfection accelerates septic shock through immunosuppression and inflammatory cascades. Genomic analysis provides critical insights for precision diagnosis and treatment of polymicrobial infections.

Indexed as

BacteremiaCoinfectionEpstein-Barr Virus InfectionsGram-Negative Bacterial InfectionsHerpesvirus 4, HumanShewanellaShock, SepticAnti-Bacterial AgentsChinaGenome, BacterialGenomicsHumansMicrobial Sensitivity TestsPhylogenyVirulence FactorsAnti-Bacterial AgentsVirulence FactorscoinfectionEpstein‐Barr virussepsisShewanella algaewhole‐genome sequencing

Identifiers

PMID41556085
PMCPMC12816973

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.