ReviewCureus2025
Nephrotoxic Effects of Endocrine-Disrupting Chemicals: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-disrupting chemicals (EDCs) are widespread environmental pollutants that interfere with hormonal regulation and are increasingly linked to kidney dysfunction. The kidney's central role in xenobiotic filtration and excretion makes it vulnerable to cumulative toxic exposures that trigger oxidative stress, inflammation, and apoptosis, leading to chronic kidney disease (CKD) and related disorders. This systematic review synthesized evidence from human, animal, and computational studies assessing exposure to multiple EDC classes, including bisphenols, phthalates, parabens, alkylphenols, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFASs), pesticides, and heavy metals, and their associations with kidney outcomes. A comprehensive search of PubMed, Scopus, Web of Science, and the Cochrane Library was conducted up to October 2025 following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality was evaluated using the AXIS tool for cross-sectional studies, the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies, the Joanna Briggs Institute (JBI) checklists, and the Toxicological Data Reliability Assessment Tool (ToxRTool). Of 42,006 records screened, 10 studies met the inclusion criteria, encompassing large population cohorts, animal experiments, and molecular docking analyses. Cross-sectional datasets, such as the National Health and Nutrition Examination Survey (NHANES), demonstrated significant associations between VOCs, phthalates, and heavy metals (particularly lead and cadmium) and increased CKD and diabetic kidney disease (DKD) risk, while some PFASs showed neutral or inverse associations. Experimental evidence confirmed that bisphenol and alkylphenol derivatives induce renal injury via oxidative stress, p53 activation, and apoptosis, and dialysis-related studies revealed iatrogenic bisphenol contamination. Overall, these findings highlight the kidney's susceptibility to environmental toxicants and emphasize the need for stricter regulation of EDC-containing materials, improved biomonitoring of cumulative exposures, and further mechanistic research to clarify dose-response relationships and long-term renal effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.