Evidence map›Paper›PMID 41555862›Full record

ReviewClinical pharmacology : advances and applications2026

The Role of Danavorexton for Perioperative Opioid-Induced Respiratory Depression and Sedation: A Narrative Review.

Alexia J Enache, Collin J Harris, Toluwanimi I Atewogbola, Aiden B De Witt, Shahab Ahmadzadeh, David W McGregor Jnr, Sahar Shekoohi, Alan D Kaye

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical pharmacology : advances and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexia J EnacheSchool of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
Collin J HarrisSchool of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
Toluwanimi I AtewogbolaSchool of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
Aiden B De WittDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
Shahab AhmadzadehDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
David W McGregor JnrDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.ORCID 0009-0007-4545-4523
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid-induced respiratory depression (OIRD) and sedation are significant perioperative complications that limit safe and effective use of opioid analgesia. Current reversal agents, such as naloxone, are effective at treating OIRD but may negatively affect pain management, leaving a critical clinical gap in perioperative pain management. The orexin system has a pivotal role in wakefulness and respiratory drive. Danavorexton is a selective orexin-2 receptor agonist that targets this system to promote arousal and respiratory function. It has emerged as a pharmacological option for OIRD and reversal for opioid sedation without compromising analgesia. Additionally, studies have shown that danavorexton can enhance tidal volume and minute ventilation in patients who are being managed with opioids. This narrative review discusses the pathophysiology of OIRD, current reversal strategies, and the emerging evidence supporting the use of Danavorexton in perioperative care. Danavorexton represents a novel and potentially transformative adjunct that could improve postoperative recovery, reduce adverse opioid-related events, and enhance patient safety in the surgical setting.

Indexed as

danavorextonopioid analgesiaopioid-induced respiratory depressionorexin receptor agonistperioperative sedation

Identifiers

PMID41555862
PMCPMC12812263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.