Evidence map›Paper›PMID 41555850›Full record

ArticlePulmonary circulation2026

Prognostic Value of Acute Vasoreactivity in Chronic Thromboembolic Pulmonary Hypertension.

Justin A G Uphus, Jiun-Ruey Hu, Shi Huang, Thomas M Hofbauer, Adelheid Panzenboeck, Roela Sadushi-Kolici, Inbal Shafran, Nika Skoro-Sajer, Christian Gerges, Evan Brittain and 1 more

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin A G UphusDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.ORCID https://orcid.org/0009-0005-2331-9705
Jiun-Ruey HuDepartment of Internal Medicine, Section of Cardiovascular Medicine Yale University New Haven USA.
Shi HuangDepartment of Medicine, Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville USA.
Thomas M HofbauerDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.
Adelheid PanzenboeckDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.ORCID https://orcid.org/0000-0001-6697-130X
Roela Sadushi-KoliciDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.
Inbal ShafranDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.
Nika Skoro-SajerDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.
Christian GergesDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.ORCID https://orcid.org/0000-0002-6777-0996
Evan BrittainDepartment of Medicine, Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville USA.
Irene M LangDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.ORCID https://orcid.org/0000-0003-0485-2692

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vasoreactivity, which refers to the reduction of mean pulmonary arterial pressure in response to inhaled vasodilators, is a well-established metric for prognostication and treatment selection in patients with pulmonary arterial hypertension. However, the role of vasoreactivity in chronic thromboembolic pulmonary hypertension is less studied. We investigated whether vasoreactivity at time of diagnosis carries prognostic value in all patients with chronic thromboembolic pulmonary hypertension, and how it relates to the effect of long-term pulmonary vasodilator treatments. Patients diagnosed with CTEPH were prospectively subjected to 40 ppm inhaled nitric oxide testing at the diagnostic right heart catheterization. Classic (acute decrease of mean pulmonary arterial pressure > 10 mmHg to a level below 40 mmHg,

Indexed as

chronic thromboembolic pulmonary hypertensioninhaled nitric oxidemean pulmonary arterial pressurepulmonary microvasculopathyvasoreactivity testing

Identifiers

PMID41555850
PMCPMC12812283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.