Evidence map›Paper›PMID 41555828›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Hearing impairment and cognitive decline: Alternative explanations to causality.

Natascha Merten, Piers Dawes, Kevin J Munro, Willa D Brenowitz

Abstract readEditorial
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natascha MertenDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-1405-1218
Piers DawesCentre for Hearing Research, School of Health and Rehabilitation Sciences, University of Queensland, Queensland, Australia.
Kevin J MunroManchester Centre for Audiology and Deafness, University of Manchester, Manchester, UK.ORCID 0000-0001-6543-9098
Willa D BrenowitzKaiser Permanente Center for Health Research, Portland, OR, USA.

Funding

Project 4: Social isolation as a driver of AD/ADRD incidence and disparitiesP01AG082653 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Jacqueline Marie Torres · 2024 to 2026
$23.6M
The Beaver Dam Offspring Study Neurocognitive Aging Study (BOSS-NCAS)-A Study on the Role of Accelerated Aging and Midlife Sensory Decline for Early Alzheimer’s Disease and Dementia in Later LifeR01AG079289 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Natascha Merten · 2022 to 2026
$3.7M
Multisensory, Motor, and Biomarker Changes in Aging and Preclinical Alzheimer's DiseaseRF1AG066837 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI MERTEN, NATASCHA · 2020 to 2023
$2.1M
Sensory Impairments, Cognitive Decline, and Dementia: What Explains the Association?K01AG062722 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRENOWITZ, WILLA DOMINO · 2019 to 2023
$652k
Evaluating the associations of hearing loss with cognitive and brain health outcomes in midlifeR21AG089427 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI BRENOWITZ, WILLA DOMINO · 2024 to 2025
$472k
NIA NIH HHS K01 AG062722NIA NIH HHS P01 AG082653NIA NIH HHS R01 AG079289NIA NIH HHS R21 AG089427NIA NIH HHS RF1 AG066837
6 · The paper itself

Abstract

Despite growing interest in hearing impairment as a potentially modifiable risk factor for dementia, the association is poorly understood. This has implications for whether treating hearing impairment can prevent or delay onset of dementia, as causation is not the only explanation for the association. In this editorial, we highlight how biases in research studies might account for the reported associations. We suggest future research using different study designs and novel biomarkers to help us overcome methodological limitations. This may allow us to determine the strength of the causal pathways linking hearing impairment to dementia, ultimately informing prevention and treatment strategies.

Indexed as

Cognition DisordersCognitive DysfunctionHearing LossCausalityHumansAlzheimer's diseasebiascausalitycognitiondementiaepidemiologyhearing lossmeasurement errorsensory lossstudy designs

Identifiers

PMID41555828
PMCPMC12822997

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.