ArticleJournal of Korean medical science2026
Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model.
Article in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Investigation of the protective effect of visnagin against cadmium toxicity in rat nephropathy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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9 authors.
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Abstract
backgroundKidney damage can result not only from the overproduction of endogenous oxalate but also from excessive dietary intake. This study investigated whether oxalate-rich Chaga mushroom induces kidney injury.
methodsWistar rats were allocated to three groups based on dosese extrapolated from a previously reported clinical case. The standard-dose group received Chaga mushroom powder at 1,281.6 mg/kg body weight (equivalent to oxalate at 183 mg/kg body weight), and the high-dose (HD) group at 3,844.8 mg/kg body weight (equivalent to oxalate at 549 mg/kg body weight); the control group received no supplements. The study assessed chronic kidney injury by evaluating renal function, histopathology, oxidative stress, and apoptosis via immunohistochemistry and immunoblot assay.
resultsThe final body weight of the HD group was significantly lower than that of the other groups (
conclusionHigh-dose consumption of Chaga mushrooms may cause kidney damage due to its high oxalate content.
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