ArticleJournal of cosmetic dermatology2026
Assessment of Subepidermal Low-Echogenic Band via High-Frequency Ultrasound for Evaluating the Efficacy of Platelet-Rich Plasma Injection in Treating Facial Skin Photoaging: A Case Series.
Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Evaluation of Thread Lifts With High-Frequency Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Review
- Skin as a sentinel and modulator of systemic aging: a translational framework for evidence-based gerotherapeutics.GeroScience · 2026Review
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
- Assessment of Subepidermal Low-Echogenic Band via High-Frequency Ultrasound for Evaluating the Efficacy of Platelet-Rich Plasma Injection in Treating Facial Skin Photoaging: A Case Series.Journal of cosmetic dermatology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFacial skin photoaging manifests as wrinkles, laxity, roughness, enlarged pores, telangiectasia, pigmentation, and dermal structural changes. Histologically, dermal collagen degradation and dermal-epidermal junction disruption form the subepidermal low-echogenic band (SLEB) on ultrasound. Platelet-rich plasma (PRP) injection promotes skin regeneration but lacks objective imaging biomarkers.
objectiveTo objectively evaluate the structural efficacy of PRP for facial photoaging by quantifying SLEB width and dermal thickness changes via high-frequency ultrasound (HFUS), alongside skin analyzer assessments.
methodsThis retrospective case series included 10 patients (Glogau I-III) receiving three monthly PRP injections. The treatment utilized a standardized dual-step protocol: manual precision injection targeting the deep dermis, followed by mechanical mesogun injection for uniform superficial coverage. SLEB width and dermal thickness were measured at four facial sites using HFUS before and 1 month after treatment. A skin analyzer assessed skin parameters. A comprehensive clinical evaluation was conducted using the Glogau classification and Global Aesthetic Improvement Scale (GAIS) for efficacy and patient satisfaction assessment.
resultsPost-treatment, HFUS revealed significant reductions in SLEB width (average decrease 29%-47%, all p < 0.001) and increases in dermal thickness (average increase 24%-51%, all p ≤ 0.003). Skin analyzer showed significant improvements in Pores, Wrinkles, Brown Spots, and Red Areas (all p < 0.05). Clinical evaluations confirmed significant improvement in Glogau classification (p < 0.01) and high patient satisfaction (100% reported improvement on GAIS). No serious adverse events were observed; only transient erythema/edema and mild pain were reported.
conclusionHFUS is a reliable, non-invasive tool for assessing PRP efficacy. SLEB width reduction serves as a sensitive, objective imaging biomarker, providing structural evidence for PRP's ability to improve photoaging damage.
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