Observational studyJournal of cachexia, sarcopenia and muscle2026
Pulmonary Obstruction and Age, Not Activity, Associate With Muscle Oxidative Impairment in Smokers With and Without COPD.
Observational study in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Reply to the letter-to-editor: "on the preserved muscle oxidative capacity in COPD patients with hypoxemia treated by long term OEuropean journal of applied physiology · 2026Article
- Preserved muscle oxidative capacity in COPD patients with hypoxemia treated by long term OEuropean journal of applied physiology · 2026Article
- Pulmonary Obstruction and Age, Not Activity, Associate With Muscle Oxidative Impairment in Smokers With and Without COPD.Journal of cachexia, sarcopenia and muscle · 2026Observational
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Authors and funding
6 authors.
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Abstract
backgroundLow muscle oxidative capacity is an extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) with unclear aetiology. We sought to characterize locomotor muscle oxidative capacity in never smokers and ever smokers with and without COPD and determine clinical and behavioural features associated with low muscle oxidative capacity.
methodsTwo hundred forty-three adults enrolled in the Muscle Health Study, an observational study ancillary to COPDGene. Gastrocnemius oxidative capacity was measured by near-infrared spectroscopy from the muscle oxygen consumption recovery rate constant (k). Physical activity was measured by accelerometry (vector magnitude units [VMU]/min). Pulmonary assessments included spirometry (FEV
resultsTwo hundred forty-one (53.1% female; 45.6% African American; 64 ± 10 years old) participants were allocated to analysis. FEV
conclusionsPhysical activity or radiographic COPD manifestations were not significantly associated with muscle oxidative impairment. Across never smokers and ever smokers with and without COPD, locomotor muscle oxidative capacity was positively associated with FEV
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Registered trials
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