Evidence map›Paper›PMID 41555513›Full record

ArticleRedox report : communications in free radical research2026

Protective role of fatty acid oxidation against epithelial barrier dysfunction in allergic asthma.

Muyun Wang, Yanan He, Haiyang Hu, Di Wu, Ximing Liao, Jing Gao, Shaoyong Gao, Huiming Yin, Kian Fan Chung, Qiang Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Muyun WangDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Yanan HeDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Haiyang HuDepartment of Vascular Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Di WuDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Ximing LiaoDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Jing GaoDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Shaoyong GaoDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Huiming YinDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital, Hunan University of Medicine, Huaihua, People's Republic of China.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Qiang LiDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Kun WangDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Wei GaoDepartment of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatty acid oxidation (FAO) is implicated in lung diseases, but its role in bronchial asthma is not fully understood. We investigated its effect on airway epithelial barrier integrity.

methodsUsing a house dust mite (HDM)-induced murine asthma model and HDM, IL-4, IL-13, or TNF-α stimulated human primary bronchial epithelial cells (BECs) and bronchial epithelial (Beas-2b) cells, we modulated FAO with L-carnitine (agonist) and Etomoxir (inhibitor). BECs and Beas-2b cells were infected with lentivirus-mediated

resultsFAO level in lungs negatively correlated with increased inflammation and tissue injury in HDM-induced asthmatic mice (all

conclusionFAO plays a protective role in the occurrence and development of asthma by maintaining airway epithelial cell homeostasis and barrier function.

Indexed as

AsthmaFatty AcidsAnimalsBronchiEpithelial CellsEpoxy CompoundsHumansMiceMice, Inbred BALB CMitochondriaOxidation-ReductionOxidative StressEpoxy CompoundsetomoxirFatty AcidsAirway epithelial barrierBronchial asthmaCarnitine palmitoyltransferase 1AEtomoxirfatty acid oxidationhouse dust miteL-carnitineOxidative stress

Identifiers

PMID41555513
PMCPMC12821354

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.