ArticleBMC veterinary research2026
Metabolomic profiling of goat seminal plasma: insights into sperm motility regulation.
Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Low sperm motility is a major limitation to the success of artificial insemination in goats, yet the metabolic basis underlying this trait remains poorly understood. Seminal plasma (SP) contains a diverse array of metabolites that support sperm function by providing energy substrates, antioxidants, and signaling molecules. This study investigated the metabolomic profile of goat seminal plasma associated with sperm motility, aiming to explore the metabolic mechanisms underlying variations in sperm motility and identify potential biomarkers associated with goat reproductive performance. Using the high-resolution liquid chromatography–mass spectrometry (LC–MS), a total of 7,374 metabolites were detected across all samples. All xenobiotic compounds detected in preliminary analyses were excluded following MS/MS confirmation. Multivariate and univariate analyses revealed several significantly different individual metabolites (false discovery rate < 0.05) between high-motility (≥ 75%) and low-motility (≤ 65%) groups. However, no metabolic pathways remained significant after false discovery rate (FDR) correction, indicating an exploratory level of evidence limited to single metabolite associations. Key discriminant metabolites included amino acids, carnitine derivatives, and antioxidants such as riboflavin and phosphocreatine, which were more abundant in the high-motility group. These findings suggest possible roles of energy metabolism, oxidative protection, and membrane stability in regulation of goat sperm motility.This work presents the most comprehensive dataset to date for goat seminal plasma, generated under controlled conditions with rigorous quality assurance. The results provide preliminary insight into the metabolite–motility relationships and offer a foundation for future targeted validation using multiple reaction monitoring and functional fertility assays.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.