Evidence map›Paper›PMID 41555391›Full record

ArticleCell & bioscience2026

The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair.

Ning Wang, Lun Yang, Yunhe Huang, Yanan Wang, Mingshan Liu, Jie Yang, Zhikai Zeng, Guobin Xie, Longhua Sun, Tianyu Han and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ning Wang *Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Lun Yang *Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Yunhe HuangJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Yanan WangJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, Departments of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Mingshan LiuJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Jie YangJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Zhikai ZengJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Guobin XieJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Longhua SunJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, Departments of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Tianyu HanJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, Departments of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. hantianyu87@163.com.
Bentong YuJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. yubentong@126.com.
Jiangbo JinJiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, the Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. 1159223713@qq.com.ORCID http://orcid.org/0000-0002-3076-7320

Funding

Cultivating Plan Program for the Leader in Science and Technology of Yunnan Province YFYPY202107First Affiliated Hospital of Zhengzhou University YQ202104National Natural Science Foundation of China 82273258，82360474， 81960523the Construction Project of Scientific Research and Innovation Team of the First Affiliated Hospital of Nanchang University YFYKCTDPY202201the Foundation of Jiangxi Education Department GJJ210213, GJJ200228, GJJ2200214the Natural Science Foundation of Jiangxi Province 20212BAB216034, 20212ACB206014,20232BAB216064Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps jxsq2023201100, jxsg2023201025
6 · The paper itself

Abstract

backgroundResistance to chemotherapy drugs is one of the significant factors for limited treatment options and poor prognosis in esophageal cancer. A study has found that SOX12 plays a role in cisplatin resistance in hepatocellular carcinoma cells, but the function and mechanism of SOX12 in cisplatin resistance in esophageal cancer are unclear.

resultsOur study found that SOX12 protein levels are significantly elevated in cisplatin-resistant esophageal cancer cell lines and in esophageal cancer cells treated with cisplatin. Knocking down SOX12 enhances the sensitivity of esophageal cancer cells to cisplatin. Additionally, we have observed that elevated SOX12 protein promotes the efficiency of DNA double-strand break repair. Mechanistically, we found that the depletion of SOX12 results in a notable reduction in the levels of RNF168 protein, while its mRNA expression remains unaffected. Furthermore, we demonstrated that SOX12 regulates RNF168 protein stability by transcriptionally repressing the expression of TRIP12 and UBR5. On the other hand, we have also discovered that RNF168 interacts with and stabilizes SOX12 protein via a ubiquitin-proteasome system.

conclusionsCollectively, our study identifies a feedback regulatory loop between SOX12 and RNF168 that promotes DNA damage repair and cisplatin resistance in esophageal cancer cells.

Indexed as

Cisplatin-resistanceDNA damage repairESCCRNF168SOX12

Identifiers

PMID41555391
PMCPMC12895629

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.