Evidence map›Paper›PMID 41555353›Full record

ArticleCell communication and signaling : CCS2026

Deficiency of osteopontin in gut epithelial cells enhances intestinal integrity by promoting gut renewal through the JAK3/STAT4 pathway in acetaminophen (APAP)-induced acute liver injury.

Chang Yu, Yihan Qian, Yuge Zhou, Yali Sang, Weifan Huang, Limeng Yang, Liyue Lu, Xing Rong, Hailong Wu, Yanjun Shi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chang Yu *Central Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yihan Qian *Central Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuge Zhou *Central Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yali SangCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Weifan HuangCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Limeng YangDepartment of Internal Medicine, Shanghai Pudong New Area Hospital of Traditional Chinese Medicine Affliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liyue LuCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xing RongCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hailong WuShanghai Key Laboratory of Molecular Imaging, Collaborative Innovation Center for Biomedicines, Shanghai University of Medicine and Health Sciences, Shanghai, China. wuhl@sumhs.edu.cn.
Yanjun ShiAbdominal Transplantation Center, General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. shiyanjunss@hotmail.com.
Xiaoni KongCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. xiaoni-kong@126.com.

Funding

National Natural Science Foundation of China 82370582National Natural Science Foundation of China 82405136Shanghai Pudong New Area Science and Technology Development Fund Institutional Public Welfare Research Special Program Healthcare Project PKJ2022-Y42the Science and Technology Commission of Shanghai Municipality 22ZR1428100The Scientific Program of Shanghai Municipal Health Commission 201940352
6 · The paper itself

Abstract

Gut barrier dysfunction is a key feature of acute liver injury (ALI) and leads to systemic immune responses (SIRS). Our previous studies have demonstrated that knockout of osteopontin (OPN) modulates antimicrobial peptide expression and reduces intestinal flora, thereby ameliorating sepsis. In this study, we employed an acetaminophen (APAP)-induced hepatotoxicity model, the leading cause of acute liver failure (ALF) worldwide, to investigate the role of intestinal epithelial-derived OPN in gut barrier integrity during ALF. We found that intestinal epithelial-specific OPN knockout mice (Opn

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryEpithelial CellsIntestinal MucosaJanus Kinase 3OsteopontinSignal TransductionAnimalsIntestinal Barrier FunctionMaleMiceMice, Inbred C57BLMice, KnockoutSTAT Transcription FactorsAcetaminophenJanus Kinase 3OsteopontinSTAT Transcription FactorsAcute liver failureGut barrierJAK3/STAT4Osteopontin

Identifiers

PMID41555353
PMCPMC12895711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.