SynthesisBMC psychiatry2026
Atopic dermatitis and psychological disorders in children and adolescents: a systematic review on comorbidities and mechanism.
Synthesis in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Early-Life High-Fat Diet Impairs Autophagy and Reduces GABANutrients · 2026Article
- The potential of targeted IL-4 therapy for the comorbidity of atopic dermatitis and attention-deficit/hyperactivity disorder in children via the skin-brain axis.Frontiers in allergy · 2026Article
- Factors Influencing Self-Management Behaviors in Patients with Atopic Dermatitis and Intervention Strategies: A Narrative Review.Patient preference and adherence · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions and intense pruritus. Its increasing global prevalence poses substantial physical and psychosocial challenges for children and adolescents, particularly adolescents in the developmental stage of identity formation. Given the paucity of exclusive adolescent studies, this review focuses on adolescents while integrating evidence from child-adolescent mixed samples to synthesize comorbidity patterns and mechanisms.
methodsThis systematic review was conducted in accordance with the PRISMA 2020 guidelines. Three electronic databases (PubMed, CNKI and PsycINFO) were searched to identify relevant studies published from the inception of each database to October 1st, 2025. Snowball search was performed by reviewing references of included studies and relevant systematic reviews/meta-analyses to avoid missing eligible literature. 66 studies were included in total, with 36 epidemiological studies summarized. Among the 36 studies, 9 (25.0%) focused exclusively on adolescents (10–19 years old), and 27 (75.0%) were mixed-age studies including children (≤9 years) and adolescents. These studies focused on the association between AD and psychiatric conditions, covering various psychiatric comorbidities including anxiety, depression, sleep disorders, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and suicide-related behaviors.
resultsEpidemiological evidence generally suggests that adolescents with AD are at an elevated risk of multiple psychiatric conditions, including depression, anxiety, sleep disturbances, suicide-related behaviors, and ASD. However, findings are heterogeneous for ADHD and schizophrenia, with some studies failing to confirm these associations. Proposed mechanisms for these associations include shared genetic susceptibilities, immune-inflammatory dysregulation, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, psychosocial stressors, and exposure to environmental allergens.
conclusionsChildren and adolescents with AD appear vulnerable to a range of psychiatric comorbidities, though evidence heterogeneity and conflicting findings (particularly for ADHD) highlight the need for caution in interpretation. Future research should focus on clarifying inconsistent associations and elucidating the biological and psychosocial pathways linking AD to psychiatric disorders, to inform targeted prevention and intervention strategies. CLINICAL TRIAL NUMBER: Not applicable.
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