Trial reportBMC anesthesiology2026
Effect of continuous intraoperative intravenous dexmedetomidine infusion on postoperative delirium in elderly patients undergoing lower extremity orthopedic surgery under neuraxial anesthesia: a prospective single-center controlled clinical trial.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Perioperative interventions in preventing postoperative delirium following orthopaedic surgery in the elderly: a Bayesian network meta-analysis.Journal of orthopaedic translation · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative delirium (POD) is a common and serious complication in elderly patients undergoing lower extremity orthopedic surgery, associated with increased morbidity and mortality. This study aims to evaluate the effect of intraoperative dexmedetomidine on POD incidence and severity in elderly orthopedic patients.
methodsThis prospective, single-center, randomized controlled trial enrolled patients aged ≥ 65 years scheduled for lower extremity orthopedic surgery under neuraxial anesthesia. Patients were randomly assigned to receive either dexmedetomidine (Group D) or placebo (Group C) in a 1:1 ratio. The primary outcome was the incidence of POD within 7 days postoperatively, assessed using the Confusion Assessment Method (CAM). Secondary outcomes included the severity of delirium, length of hospital stay, incidence of postoperative nausea and vomiting (PONV), postoperative visual analog scale (VAS) pain scores at 6 h, 12 h, 24 h, and 48 h, patient-controlled analgesia (PCA) usage, sufentanil consumption, and other adverse events.
resultsA total of 200 patients were randomized, with 92 in Group D and 91 in Group C completing the study. The incidence of POD was significantly lower in Group D (9.78%) compared to Group C (20.88%) (χ² = 4.35, p = 0.037). The severity of delirium was also lower in Group D (Z = -2.07, p = 0.038). There were no significant differences between groups in terms of PONV incidence (p = 0.641), VAS scores at any time point (all p > 0.05), PCA usage (p = 0.532), sufentanil consumption (p = 0.591), or other adverse events (p > 0.05).
conclusionIntraoperative dexmedetomidine infusion significantly reduces the incidence and severity of POD in elderly patients undergoing lower extremity orthopedic surgery. This intervention appears safe and effective, with no significant increase in adverse events or impact on postoperative pain management.
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