Evidence map›Paper›PMID 41555089›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Impact of carbon-ion radiotherapy on tumor hypoxia detected by

Jian Chen, Jingyi Cheng, Ningyi Ma, Jingfang Mao, Kai-Liang Wu, Guo-Liang Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jian Chen *Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of radiation oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, No. 4365, Kangxin Road, Shanghai, 201321, China.
Jingyi Cheng *Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of radiation oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, No. 4365, Kangxin Road, Shanghai, 201321, China.
Ningyi MaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of radiation oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, No. 4365, Kangxin Road, Shanghai, 201321, China.
Jingfang MaoDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of radiation oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, No. 4365, Kangxin Road, Shanghai, 201321, China. jingfang.mao@sphic.org.cn.
Kai-Liang WuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of radiation oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, No. 4365, Kangxin Road, Shanghai, 201321, China.
Guo-Liang JiangDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai Key Laboratory of radiation oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Fudan University Cancer Hospital, No. 4365, Kangxin Road, Shanghai, 201321, China.

Funding

Shanghai Municipal Health Commission 202140009Shanghai Municipal Health Commission 202240052Shanghai Pudong New Area Health Commission PW2022A-29Shanghai Pudong New Area Health Commission PW2023A-10Shanghai Pudong New Area Science and Technology Development Fund for the People's Livelihood Research Project PKJ2023-Y41Shanghai Pudong New Area Science and Technology Development Fund for the People's Livelihood Research Project PKJ2023-Y43Shanghai Pudong New Area Science and Technology Development Fund for the People's Livelihood Research Project PKJ2024-Y59Shanghai Science and Technology Development Foundation 20ZR1453300
6 · The paper itself

Abstract

purposeThe study aimed to assess the impact of carbon-ion radiotherapy (CIRT) on intratumoral hypoxia in patients with locally advanced non-small cell lung cancer (LA-NSCLC) and the predictive value of

methodsWe retrospectively analyzed patients with stage IIB-IIIC NSCLC treated with CIRT who underwent baseline

resultsThirty-seven eligible patients with 42 ROIs were included. Significant reductions in all

conclusionTumor hypoxia detected by

Indexed as

Carcinoma, Non-Small-Cell LungHeavy Ion RadiotherapyLung NeoplasmsMisonidazolePositron Emission Tomography Computed TomographyTumor HypoxiaAgedAged, 80 and overFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedRadiopharmaceuticalsRetrospective StudiesFluorodeoxyglucose F18fluoromisonidazoleMisonidazoleRadiopharmaceuticals18F-fluorodeoxyglucose18F-fluoromisonidazoleCarbon-ion radiotherapyHypoxiaNon-small cell lung cancerParticle therapy

Identifiers

PMID41555089
PMCPMC13121404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.