Evidence map›Paper›PMID 41555086›Full record

ArticleNature immunology2026

Cell cycle arrest enhances CD8

Floortje J van Haften, Tetje C van der Sluis, Hanna S Hepp, Nils Mülling, Reza Nadafi, Bharath Sampadi, Suzanne van Duikeren, J Shirin Mostert, Rosemarijn van der Sterre, Peter A van Veelen and 18 more

Abstract read
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Low-dose docetaxel reprograms CAR T cells for enhanced solid tumor immunity.Journal of experimental & clinical cancer research : CR · 2026
    Article
  4. Cell Cycle Sensing Shapes Human T Cell Fate and Exhaustion Programs.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Floortje J van Haften *Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-4089-7142
Tetje C van der Sluis *Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1804-1647
Hanna S HeppDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0009-0009-5126-5731
Nils MüllingDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3534-233X
Reza NadafiDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Bharath SampadiDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Suzanne van DuikerenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7391-5832
J Shirin MostertDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0009-0000-2993-8455
Rosemarijn van der SterreDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Peter A van VeelenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-7898-9408
Graham A HeieisCenter for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Dominique M B VeerkampDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Thomas H WesselinkDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Ward VleeshouwersDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1264-3559
Macha BeijnesDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Iris N PardieckDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Eralin L F van HorssenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0009-0009-8700-076X
Anne F de GrootDepartment of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.
Manon van der PloegDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Judith R KroepDepartment of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.
Noel F C C de MirandaDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-6122-1024
Sabina Y van der ZandenDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-5587-1514
Jacques NeefjesDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-6763-2211
Hailiang MeiDepartment of Biomedical Data Sciences, Sequencing Analysis Support Core, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1781-5508
Alfred C O VertegaalDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Bart EvertsCenter for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3764-5131
Sjoerd H van der BurgDepartment of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-6556-0354
Ramon ArensDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands. r.arens@lumc.nl.ORCID http://orcid.org/0000-0001-5058-4110

Funding

KWF Kankerbestrijding (Dutch Cancer Society) 11750Leids Universitair Medisch Centrum (Leiden University Medical Center) Gisela ThierNederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) Vici 724016003
6 · The paper itself

Abstract

Cell cycle-inhibiting chemotherapeutics are widely used in cancer treatment. Although the primary aim is to block tumor cell proliferation, their clinical efficacy also involves specific effector CD8

Indexed as

CD8-Positive T-LymphocytesCell Cycle CheckpointsGlucoseInterleukin-2Adoptive TransferAnimalsCell DifferentiationCell ProliferationGlycolysisLymphocyte ActivationMechanistic Target of Rapamycin Complex 1Metabolic ReprogrammingMiceMice, Inbred C57BLSignal TransductionSTAT5 Transcription FactorGlucoseInterleukin-2Mechanistic Target of Rapamycin Complex 1STAT5 Transcription Factor

Identifiers

PMID41555086
PMCPMC12956598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.