Evidence map›Paper›PMID 41555085›Full record

ArticleNature immunology2026

Unraveling CD8 lineage decisions reveals that functionally distinct CD8

Miho Shinzawa, Nicole Ramos, Khanh Bui, William Hajjar, Assiatu Crossman, Xiongfong Chen, Margaret Cam, Yousuke Takahama, Alfred Singer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miho ShinzawaExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7174-2464
Nicole RamosExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Khanh BuiExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
William HajjarExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0003-7796-6495
Assiatu CrossmanExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5746-0073
Xiongfong ChenCCR Collaborative Bioinformatics Resource, Office of Science and Technology Resources, Office of Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Margaret CamCCR Collaborative Bioinformatics Resource, Office of Science and Technology Resources, Office of Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yousuke TakahamaThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4992-9174
Alfred SingerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. singera@nih.gov.ORCID http://orcid.org/0000-0002-6780-5108

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymocytes signaled by T cell antigen receptors to undergo positive selection acquire different functional fates while migrating through the thymus, but how this occurs remains uncertain. We now report that encoding CD8 co-receptors in both Cd4 and Cd8 gene loci modulates major histocompatibility complex (MHC-I) class I T cell antigen receptor signaling duration to generate all potential CD8

Indexed as

CD8-Positive T-LymphocytesHistocompatibility Antigens Class IPeptidesThymocytesThymus GlandAnimalsCell LineageClonal Selection, Antigen-MediatedMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicProteasome Endopeptidase ComplexReceptors, Antigen, T-CellSignal TransductionHistocompatibility Antigens Class IPeptidesProteasome Endopeptidase Complexproteasome subunit beta5t, mouseReceptors, Antigen, T-Cell

Identifiers

PMID41555085
PMCPMC13043308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.