ReviewNeuroscience bulletin2026
Research Progress on the Biological Function and Homeostatic Disruption of Microglia in the Pathogenesis of Major Depressive Disorder.
Review in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a major global public health issue. The recurrent episodes of depression and its unpredictable suicide risk have posed a critical medical challenge, highlighting the urgent need for an in-depth investigation into its underlying mechanisms. While the conventional hypothesis of monoamine neurotransmitter depletion is the primary cause of major depressive disorder (MDD), this theory does not entirely explain the complexity and clinical variability of MDD. The presence of treatment-resistant depression (TRD), as a subgroup of MDD, serves as compelling evidence. The immune-inflammation hypothesis has gained increasing attention, with a growing focus on the pivotal role of microglia in this framework. Microglia, the resident immune cells of the central nervous system, sustain homeostasis through self-renewal in adulthood. They are essential for regulating neuron survival, apoptosis, and synaptic plasticity under normal physiological conditions. Under pathological situations, such as traumatic injury, infection, and psychological stress, microglia receive stimulating signals to promptly respond to events. When microglia homeostasis is disrupted, they become over-activated, releasing pro-inflammatory cytokines, activating related signaling pathways, and disrupting neurotransmitter metabolism. This triggers neuroinflammation, oxidative stress, and mitochondrial dysfunction, which hinder neurogenesis, disrupt neural circuits, and ultimately contribute to MDD progression, or even potentially advance it to TRD. This review focuses on the relationship between the biology of microglia and MDD, providing a comprehensive analysis of microglial biological characteristics, factors affecting microglia function, and underlying mechanisms associated with MDD. In conclusion, this review provides a novel perspective on the pathogenesis of MDD from the angle of microglial homeostasis imbalance, aiming to lay a theoretical basis for subsequent investigation of the mechanism. In addition, based on the mechanism of neuroinflammation caused by microglial homeostasis imbalance in MDD, this review aims to offer two new promising therapeutic approaches for MDD and even its progression to the TRD stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.