ArticleJournal of perinatology : official journal of the California Perinatal Association2026
A FAR-Out approach for evaluating the impact of clinical practice changes on severe intracranial hemorrhage in preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo develop an organizational framework that examines the individual contributions of modifiable clinical interventions and non-modifiable physiologic variables on the fluctuating rate of intraventricular hemorrhage (grades 3/4) or death<4 days over time. STUDY
designWe developed the Frequency-Adjusted-Risk-difference-versus-OUTcome (FAR-Out) approach to examine risk-differences and risk-frequencies during defined study epochs. We used FAR-Out to study changes in sIVH/death<4 d rates after implementing a set of improved-practice guidelines in a preterm population (23
resultsEpoch-to-epoch variations in FAR-Out Risk Scores track closely (Pearson's r = 0.974) with epoch-to-epoch variations in sIVH/death<4 d rates. Post-implementation changes in sIVH/death <4 d rates were mostly associated with fluctuations in individual non-modifiable risks (immaturity/illness severity) rather than with changes in adherence to the guidelines' modifiable practices.
conclusionClose correlation between FAR-Out Risk Scores and sIVH/death < 4 d rates supports the FAR-Out approach's potential usefulness in examining the relative influence of individual risk factors on the incidence of sIVH/death <4 d.
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